Insulin-Like Growth Factor I: A Possible Modulator of Intercellular Communication in the Brain

  • Mohan K. Raizada
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)


Insulin-like growth factor I (IGF-I) is produced by the liver in response to growth hormone (GH), and plays a key mediator in its physiological responses. In addition, IGF-I has also been implicated in a wide variety of trophic and metabolic actions in the peripheral tissues. In recent years it has become evident that the liver, although the major site, is not the sole site of IGF-I synthesis and secretion. In fact, a number of peripheral tissues as well as the central nervous system (CNS) has been documented to locally synthesize this hormone. This has led to the proposal that locally produced IGF-I may exert physiological effects in an autocrine and paracrine fashion.


Growth Hormone Astrocytic Glial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    VanWyk, J.J. (1984). In: Hormonal Proteins and Peptides ,Eds. Li, C.H., Academic Press, New York, pp. 81.Google Scholar
  2. 2.
    Czech, M.P. (1989). Cell 59:235.PubMedCrossRefGoogle Scholar
  3. 3.
    Gammeltoft, S. (1989). In: Peptide Hormones as Prohormones. Ellis Harwood Limited, pp. 176.Google Scholar
  4. 4.
    dePablo, F., Scott, LA. and Roth, J. (1990). Endocrine Rev. Vol. 11, 558.CrossRefGoogle Scholar
  5. 5.
    Hansson, H-A (1990). In: Current Medical Literature: Growth and Growth Factors. 5(1), pp. 3, Royal Society of Medicine.Google Scholar
  6. 6.
    Daughaday, W.H. (1989). In: Molecular and Cellular Biology of Insulin-Like Growth Factors and Their Receptors. Eds. LeRoith, D. and Raizada, M.K. Plenum Press, New York, pp. 1.CrossRefGoogle Scholar
  7. 7.
    Sara, V.R. and Hall, K. (1990). Physiol. Rev. 70:591.PubMedGoogle Scholar
  8. 8.
    Sara, V.R. and Carlsson-Skwirut, C. (1990). In: Growth Factors: From Genes to Clinical Application. Eds. Sara, V.R., Hall, K. and Low, H. Raven Press, New York, pp. 179.Google Scholar
  9. 9.
    LeRoith, D., Roberts, C.T., Werner, H., Raizada, M.K. and Adamo, M. (1991). In: Neurotrophic Factors. Eds. Loughlin, S.E. and Fallon, J.H., Academic Press, Orlando, FL., 1991.Google Scholar
  10. 10.
    Carlsson-Skwirut, C., Jornvall, H., Holmgreu, A., Andersson, C., Bergman, T., Lundquist, G., Sjogren, B. and Sara, V.R. (1986). FEBS Lett. 201:3656.Google Scholar
  11. 11.
    Sara, V.R., Carlsson-Skwirut, C., Andersson, C., Hall, E., Sjogren, B., Holmgren, A. and Jornvall, H. (1986). Proc. Natl. Acad. Sci., USA 83:4904.PubMedCrossRefGoogle Scholar
  12. 12.
    Francis, L.G., Reed, L.C., Ballard, F.J., Bagley, C.J., Upton, F.M., Gravestock, P.M. and Wallace, J.C. (1986). Biochem. J. 233:203.Google Scholar
  13. 13.
    Karey, K.P., Marquardt, H. and Sirbasku, (1989). Blood 74:1084.PubMedGoogle Scholar
  14. 14.
    Ogasawara, M., Karey, K.P., Marquardt, H. and Sirbasku, (1989). Biochem. 28:2710.CrossRefGoogle Scholar
  15. 15.
    Rotwein, P., Burgess, S.K., Milbrandt, J.D. and Krause, J.E. (1988). Proc. Natl. Acad. Sci., USA 85:265.PubMedCrossRefGoogle Scholar
  16. 16.
    Sandberg, A-C, Engberg, C., Lake, M., vonHolst, H. and Sara, V.R. (1988). Neurosci. Lett. 93:114.PubMedCrossRefGoogle Scholar
  17. 17.
    Wood, T.L., Berelowitz, M. and McKelvy, J.F. (1989). In: Molecular and Cellular Biology of Insulin-Like Growth Factors and Their ReceptorsEds. LeRoith, D. and Raizada, M.K., Plenum Press, New York, pp. 209.CrossRefGoogle Scholar
  18. 18.
    Werther, G.A., Abate, M., Hogg, A., Cheesman, H., Oldfield, B., Hards, D., Hudson, P., Power, B., Freed, K. and Herington, A.C. (1990). Mol. Endocrinol4:773.PubMedCrossRefGoogle Scholar
  19. 19.
    Bondy, C.A., Werner, H., Roberts, C.T. and LeRoith, D. (1990). Mol. Endocrinol. 4:1386.PubMedCrossRefGoogle Scholar
  20. 20.
    Werner, H., Woloschak, M., Adamo, M., Shen-orr, Z, Roberts, C.T. and LeRoith, D. (1989). Proc. Natl. Acad. Sci., USA 86:7451.PubMedCrossRefGoogle Scholar
  21. 21.
    Sara, V.R., Sandberg-Nordquvist, A-C, Carlsson-Skwirut, C, Bergman, T. and Ayer-LeLievre, (1991). In: Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Eds. Raizada, M.K. and LeRoith, D., Plenum Press, New York, pp.Google Scholar
  22. 22.
    Andersson, I.K., Edwall, D., Norstedt, G., Rozell, B., Skottner, A. and Hansson, H-A (1988). Acta. Physiol. Scand. 132:167.PubMedCrossRefGoogle Scholar
  23. 23.
    Adamo, M., Werner, H., Fransworth, W., Roberts, C.T., Raizada, M.K. and LeRoith, D. (1989). Endocrinol. 123:2565.CrossRefGoogle Scholar
  24. 24.
    Lowe, Jr. W.L., Roberts, C.T., Lasky, S.R. and LeRoith, D. (1987). Proc. Natl. Acad. Sci., USA84:8946.PubMedCrossRefGoogle Scholar
  25. 25.
    Raizada, M.K. (1983). Exp. Cell. Res. 133:261.CrossRefGoogle Scholar
  26. 26.
    Mathews, L-S, Norstedt, G. and Palmiter, R.D. (1986). Proc. Natl. Acad. Sci., USA 83:9343.PubMedCrossRefGoogle Scholar
  27. 27.
    Hynes, M.A., VanWyk, J.J., Brooks, P.J., D’Ercole, A.J., Jansen, M. and Lund, P.K. (1987). Mol. Endocrinol. 1:233.PubMedCrossRefGoogle Scholar
  28. 28.
    Berelowitz, M. (1989). In: Molecular and Cellular Biology of Insulin-Like Growth Factors and Their Receptors. Eds. LeRoith, D. and Raizada, M.K., Plenum Press, New York, pp. 25.CrossRefGoogle Scholar
  29. 29.
    Adamo, M., Raizada, M.K. and LeRoith, D. (1989). Mol. Neurobiol. 3:71.PubMedCrossRefGoogle Scholar
  30. 30.
    Shemer, J., Raizada, M.K., Masters, B.A., Ota, A. and LeRoith, D. (1987). J. Biol. Chem. 262:6793.Google Scholar
  31. 31.
    Shemer, J., Adamo, M., Raizada, M.K., Heffez, D., Zick, Y. and LeRoith, D. (1989). J. Mol. Neurosci. 1:3.PubMedCrossRefGoogle Scholar
  32. 32.
    McElduff, A., Poronnik, P., Baxter, R.C. and William, P. (1988). Endocrinol. 122:1933CrossRefGoogle Scholar
  33. 33.
    Sara, V.R., Hall, K., VonHoltz, H., Humbel, R., Sjogren, B. and Wtterberg, (1982). Neurosci. Lett. 34:39.PubMedCrossRefGoogle Scholar
  34. 34.
    Gammeltoft, S., Haselbacher, G.K., Humbel, R.E., Fehlman, M. and VanObberghen, E. (1985). EMBO Journal ,4:3407.PubMedGoogle Scholar
  35. 35.
    Heidenreich, K.A., Freidenberg, G.R., Figlewicz, D.P. and Gilmore, P.R. (1986). Reg. Peptides ,15:301.CrossRefGoogle Scholar
  36. 36.
    McMorris, F.A., Smith, T.M., Desalvo, S. and Furlane, R.W. (1986). Proc. Natl. Acad. Sci., USA83:822.PubMedCrossRefGoogle Scholar
  37. 37.
    McMorris, F.A. and Dubois-Dalegn, M. (1988). J. Neurosci. Res. ,21:199.PubMedCrossRefGoogle Scholar
  38. 38.
    Masters, B.A., Werner, H., Roberts, C.T., LeRoith, D. and Raizada, M.K. (1991). Reg. Peptides (In Press).Google Scholar
  39. 39.
    Lenoir, D. and Honegger, P. (1983). Dev. Brain Res. 7:380.CrossRefGoogle Scholar
  40. 40.
    Debbage, P.L (1986). J. Neurological Sci. 72:319.CrossRefGoogle Scholar
  41. 39.
    Van der Pal, R.H.M., Koper, J.W., VanGolde, L.M.G. and Lopes-Cardozo, M. (1988). J. Neurosci. Res. 19:483.PubMedCrossRefGoogle Scholar
  42. 42.
    Saneto, R.P., Low, K.G., Melner, M.H. and deVellis, J. (1988). J. Neurosci. Res. 21:210.PubMedCrossRefGoogle Scholar
  43. 43.
    Carson, M. (1990). PhD Dissertation, University of Pennsylvania.Google Scholar
  44. 44.
    Werner, H., Raizada, M.K., Mudd, L.M., Foyt, H.L., Simpson, I.A., Roberts, C.T. and LeRoith, D. (1989). Endocrinol. 123:314.CrossRefGoogle Scholar
  45. 45.
    Masters, B.A., Werner, H., Roberts, C.T., LeRoith, D. and Raizada, M.K. (1991). Endocrinol. (In Press).Google Scholar
  46. 46.
    Nielsen, F.C., Wang, E. and Gammeltoft, S. (1991). J. Neurochem. 56:12.PubMedCrossRefGoogle Scholar
  47. 47.
    Knusel, B., Michel, P.P., Schwaber, J.S. and Hefti, F. (1990). J. Neurosci. 10:558.PubMedGoogle Scholar
  48. 48.
    Ishii, D.N. and Recio-Pinto, E. (1987). In: Insulin, Insulin-Like Growth Factors, and Their Receptors in the CNS. Eds. Raizada, M.K., Phillips, M.I. and LeRoith, D., Plenum Press, New York, pp. 315.CrossRefGoogle Scholar
  49. 49.
    Nilsson, L., Sara, V.R. and Nordberg, (1988). Neurosci. Lett. 88:221.PubMedCrossRefGoogle Scholar
  50. 50.
    Knusel, B. and Hefti, (1991). In: Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Eds. Raizada, M.K. and LeRoith, D., Plenum Press, New York.Google Scholar
  51. 51.
    Marks, J.L., King, M.G. and Baskin, D. (1991). In: Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Eds. Raizada, M.K. and LeRoith, D., Plenum Press, New York.Google Scholar
  52. 52.
    Brewer, M.T., Stetler, G.L, Squires, C.H., Thompson, R.C., Busby, W.H. and Clemmons, D.R. (1988). Biochem. Biophys. Res. Commun. 152:1289.PubMedCrossRefGoogle Scholar
  53. 53.
    Margot, J. B., Binhert, C., Mary, J.L., Landwehr, J., Heinreich, G. and Schwander, J. (1989). Mol. Endocrinol. 3:1053.PubMedCrossRefGoogle Scholar
  54. 54.
    Shimisaki, S., Koba, A., Mercado, M., Shimonaka, M. and Ling, N. (1989). Biochem. Biophys. Res. Commun. 165:905.Google Scholar
  55. 55.
    Hossenlopp, P., Seurin, D., Segovia-Quinson, B. and Binoux, M. (1986). FEBS Lett. 208:439.PubMedCrossRefGoogle Scholar
  56. 56.
    Romanus, J.A., Tseng, L.Y.H., Yang, Y.W.H. and Rechler, M.M. (1989). Biochem. Biophys. Res. Commun. 163:875.PubMedCrossRefGoogle Scholar
  57. 57.
    Roghani, M., Hossenlopp, P., Lepage, P., Ballard, A. and Binoux, M. (1989). FEBS Lett. 255:253.PubMedCrossRefGoogle Scholar
  58. 58.
    Donovan, S.M., Oh, Y., Pham, H. and Rosenfeld, R. (1989). Endocrinol. 125:2621.CrossRefGoogle Scholar
  59. 59.
    Ocrant, I., Fay, C.T. and Parmelee, J.T. (1990). Endocrinol. 127:1260.CrossRefGoogle Scholar
  60. 60.
    Han, V.K.M., Lauder, J.M. and D’Ercole, A.J. (1988). J. Neurosci. 8:3135.PubMedGoogle Scholar
  61. 61.
    Ocrant, I., Pham, H., Oh, Y. and Rosenfeld, R.G. (1989). Biochem. Biophys, Res. Commun. 159:1316.CrossRefGoogle Scholar
  62. 62.
    Lamson, G., Pham, H., Oh, Y., Ocrant, I., Schwander, J. and Rosenfeld, R.G. (1989). Endocrinol. 123:1100.CrossRefGoogle Scholar
  63. 63.
    Rosenberg, P.A. and Dichter, M.A. (1989). J. Neurosci. 9:2654.PubMedGoogle Scholar
  64. 64.
    Baker, S.P., Sumners, C., Pitha, J. and Raizada, M.K. (1986). J. Neurochem. 46:1318.Google Scholar
  65. 65.
    Bowman, C.L. and Kimelberg, H.K. (1987). Brain Res. 423:403.PubMedCrossRefGoogle Scholar
  66. 66.
    Richards, E.M., Sumners, C., Chou, Y-C, Raizada, M.K. and Phillips, M.I. (1989). J. Neurochem. 53:287.PubMedCrossRefGoogle Scholar
  67. 67.
    Puig, J.F., Pacitti, A.J., Guzman, N.J., Crews, F.T., Sumners, C. and Raizada, M.K. (1990). Brain Res. 527:318.PubMedCrossRefGoogle Scholar
  68. 68.
    Olson, J.A., Shiverick, K.T., Ogilvie, S., Buhi, W.C. and Raizada, M.K. (1991). Proc. Natl. Acad. Sci., USA 88: (In Press).Google Scholar
  69. 69.
    Morrison, R.S., Kornblym, H.I., Leslie, F.M. and Bradshaw, R.A. (1987). Science 238:72.PubMedCrossRefGoogle Scholar
  70. 70.
    Wang, S-L, Shiverick, K.T., Ogilvie, S., Dunn, R. and Raizada, M.K. (1989). Endocrinol. 124:240.CrossRefGoogle Scholar
  71. 71.
    Brenneman, D.E., Neale, E.A., Foster, G.A., D’Autremont, S.W. and Westbrook, G.L. (1987). J. Celt Biol. 104:1603.CrossRefGoogle Scholar
  72. 72.
    Clemmons, D.R., Thrailkill, K.M., Handwerger, S. and Busby, W.H., Jr. (1990). Endocrinol. 127:643.CrossRefGoogle Scholar
  73. 73.
    Saneto, R.P. and deVellis, J. (1987). In: Neurochemistry, A Practical Approach. Eds. Turner, A.J. and Bachelard, H.S., IRL Press, Washington, DC, pp. 27.Google Scholar
  74. 74.
    Sapolsky, R.M. (1985). J. Neurosci. 5:1228.PubMedGoogle Scholar
  75. 75.
    Sapolsky, R.M., Krey, L.M. and McEwen, B.S. (1986). Endocrine Reviews ,7:284.PubMedCrossRefGoogle Scholar
  76. 76.
    Horner, H.C., Packan, D.R. and Sapolsky, R.M. (1990). Neuroendocrine52:57.CrossRefGoogle Scholar
  77. 77.
    Rydzewski, B., Roberts, C.T., LeRoith, D., Sumners, C. and Raizada, M.K. (1991). Submitted.Google Scholar
  78. 78.
    Chou, Y-C (1990). Ph.D. Dissertation, University of Florida.Google Scholar
  79. 79.
    Hoibrook, N.J., Grasso, R. and Hackney, J. (1981). J. Neurosci. Res. 6:75.CrossRefGoogle Scholar
  80. 80.
    Meyer, J., Leveille, P.J., deVellis, J. and McEwen, B.S. (1982). J. Neurochem. 39:423.PubMedCrossRefGoogle Scholar
  81. 81.
    Kimar, S. and deVellis, J. (1988). In: Glial Cell Receptors Ed. Kimelberg, H.K., Raven Press, New York, pp. 243.Google Scholar
  82. 82.
    Berlinger, J.A., Bennett, K. and deVellis, J. (1978). J. Cell Physiol. 94:321.CrossRefGoogle Scholar
  83. 83.
    Morrison, R.S., deVellis, J., Lee, Y.L., Bradshaw, R.A. and Eng, L.F. (1985). J. Neurosci. Res. 14:167.PubMedCrossRefGoogle Scholar
  84. 84.
    Armelin, M.C.S., Stocco, R.C. and Armelin, H.A. (1983). J. Cell Biol. 97:455.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Mohan K. Raizada
    • 1
  1. 1.Department of Physiology, JHMHCUniversity of Florida, College of MedicineGainesvilleUSA

Personalised recommendations