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Distribution of Insulin-Like Growth Factor 1 (IGF-1) and 2 (IGF-2) Receptors in the Hippocampal Formation of Rats and Mice

  • Charles R. Breese
  • Anselm D’Costa
  • Rosemarie M. Booze
  • William E. Sonntag
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)

Abstract

Since the discovery of specific receptors in the brain for insulin-like growth factor-1 and 2 (IGF-1 and IGF-2), there has been an increased interest in the role of these peptides as neurotrophic factors and/or neuromodulators in the central nervous system. Receptors for IGF-1 and IGF-2 have been characterized in brain membrane homogenates1–6 and localized to specific brain regions utilizing in vitro receptor autoradiographic and immunological techniques7–14. Competitive binding and affinity cross-linking studies have demonstrated that IGFs bind to two distinct receptors. The IGF-1 (type 1) receptor is structurally similar to the insulin receptor, consisting of 2 extracellular alpha subunits and 2 transmembranous beta subunits (approximately 130 and 95 kDa respectively)15–17. The IGF-2 (type 2) receptor consists of a single chain glycoprotein of approximately 250 kDa, which also binds mannose-6-phosphate18–22. Radioligand binding studies have demonstrated crossreactivity of the IGFs and insulin at the receptor level. The type I IGF receptor has higher affinity for IGF-1 than IGF-2 and insulin, and the type II IGF receptor binds IGF-2 with considerably higher affinity than IGF-1, and does not recognize insulin2,23.

Keywords

Hippocampal Formation Receptor Binding Assay Receptor Autoradiography Neurite Formation Biophysical Research Communication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Charles R. Breese
    • 1
  • Anselm D’Costa
    • 1
  • Rosemarie M. Booze
    • 1
  • William E. Sonntag
    • 1
  1. 1.Department of Physiology and Pharmacology, Bowman Gray School of MedicineWake Forest UniversityWinston-SalemUSA

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