Abstract
Since the discovery of specific receptors in the brain for insulin-like growth factor-1 and 2 (IGF-1 and IGF-2), there has been an increased interest in the role of these peptides as neurotrophic factors and/or neuromodulators in the central nervous system. Receptors for IGF-1 and IGF-2 have been characterized in brain membrane homogenates1–6 and localized to specific brain regions utilizing in vitro receptor autoradiographic and immunological techniques7–14. Competitive binding and affinity cross-linking studies have demonstrated that IGFs bind to two distinct receptors. The IGF-1 (type 1) receptor is structurally similar to the insulin receptor, consisting of 2 extracellular alpha subunits and 2 transmembranous beta subunits (approximately 130 and 95 kDa respectively)15–17. The IGF-2 (type 2) receptor consists of a single chain glycoprotein of approximately 250 kDa, which also binds mannose-6-phosphate18–22. Radioligand binding studies have demonstrated crossreactivity of the IGFs and insulin at the receptor level. The type I IGF receptor has higher affinity for IGF-1 than IGF-2 and insulin, and the type II IGF receptor binds IGF-2 with considerably higher affinity than IGF-1, and does not recognize insulin2,23.
Keywords
- Hippocampal Formation
- Receptor Binding Assay
- Receptor Autoradiography
- Neurite Formation
- Biophysical Research Communication
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References
Sara, V.R., K. Hall, H. Von Holtz, R. Humbel, B. Sjogren, L. Wtterberg (1982) Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain. Neuroscience letters 34:39–44.
Goodyer, C.G., L. De Stephano, W.H. Lai, H.J. Guyda, and B.I. Posner (1984) Characterization of insulin-like growth factor receptors in rat anterior pituitary, hypothalamus, and brain. Endocrinology 114:1187–1195.
Gammeltoft, S., G.K. Haselbacher, R.E. Humbel, M. Fehlmann, and E. Van Obberghen (1985) Two types of receptor for insulin-like growth factors in mammalian brain. Embo Journal 4:3407–3412.
Heidenreich, K.A., G.R. Freidenberg, D.P. Figlewicz, and P.R. Gilmore (1986) Evidence for a subtype of insulin-like growth factor I receptor in brain. Regulatory Peptides 15:301–310.
Burgess, S.K., S. Jacobs, P. Cuatrecasas, N. Sahyoun (1987) Characterization of a neuronal subtype of insulin-like growth factor I receptor. Journal of Biological Chemistry 62:1618–1687.
Rosenfeld, R.G., H. Pham, B.T. Keller, R.T. Borchardt, and W.M. Pardridge (1987) Demonstration and structural comparison of receptors for insulin-like growth factor-l and -II (IGF-I and -II) in brain and blood-brain barrier. Biochemical &Biophysical Research Communications 149:159–166.
Bohannon, N.J., E.S. Corp, B.J. Wilcox, D.P. Figlewicz, D.M. Dorsa, and D.G. Baskin (1988) Localization of binding sites for insulin-like growth factor-1 (IGF-I) in the rat brain by quantitative autoradiography. Brain Research 444:205–213.
Lesniak, M.A., J.M. Hill, W. Kiess, M. Rojeski, C.B. Pert, J. Roth, (1988) Receptors for insulin-like growth factors I and II: Autoradiographic localization in rat brain and comparison to receptors for insulin. Endocrinology 123:2089–2099.
Mendelsohn, L.G., M.C. Smith V.L. Lucaites, G.A. Kerchner, and B. Ghetti (1988) Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice. Brain Research 458:361–366.
Smith, M., J. Clemens, G.A. Kerchner, and L.G. Mendelsohn (1988) The insulin-like growth factor-ll (IGF-II) receptor of rat brain: regional distribution visualized by autoradiography. Brain Research 445:241–246.
Adem, A., S.S. Jossan, R. d’Argy, P.G. Gillberg, A. Nordberg, B. Winblad, and V. Sara (1989) Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization. Brain Research 503:299–303.
Matsuo, K., M. Niwa, M. Kurihara, K. Shigematsu, S. Yamashita, M. Ozaki, and S. Nagataki (1989) Receptor autoradiographic analysis of insulin-like growth factor-l (IGF-I) binding sites in rat forebrain and pituitary gland. Cellular &Molecular.Neurobiology. 9:357–367.
Sklar, M.M., W. Kiess, C.L. Thomas, and S.P. Nissley (1989) Developmental expression of the tissue insulin-like growth factor ll/mannose 6-phosphate receptor in the rat. Measurement by quantitative immunoblotting. Journal of Biological Chemistry 264:16733–16738.
Valentino, K.L., I. Ocrant, and R.G. Rosenfeld (1990) Developmental expression of insulin-like growth factor-II receptor immunoreactivity in the rat central nervous system. Endocrinology 126:914–920.
Chernausek, S.D., S. Jacobs, and J.J. Van Wyk (1981) Structural similarities between human receptors for somatomedin C and insulin: analysis by affinity labeling. Biochemistry 20:7345–7350.
Czech, M.P. (1982) Structural and functional homologies in the receptors for insulin and the insulin-like growth factors. Cell 31:8–10.
McElduff, A., P. Poronnik, R.C. Baxter, and P. Williams (1988) A comparison of the insulin and insulin-like growth factor I receptors from rat brain and liver. Endocrinology 122: 1933–1939.
Roth, R.A., C. Stover, J. Hari, D.O. Morgan, M.C. Smith, V. Sara, and V.A. Fried (1987) Interactions of the receptor for insulin-like growth factor II with mannose-6-phosphate and antibodies to the mannose-6-phosphate receptor. Biochemical &Biophysical Research Communications 149:600–606.
Kiess, W., G.D. Blickenstaff, M.M. Sklar, C.L. Thomas, S.P. Nissley, and G.G. Sahagian (1988) Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor. Journal of Biological Chemistry 263:9339–9344.
MacDonald, R.G., S.R. Pfeffer, L. Coussens, M.A. Tepper, C.M. Brocklebank, J.E. Mole, J.K. Anderson, E. Chen, M.P. Czech, and A. Ullrich (1988) A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. Science 239:1134–1137.
Tong, P.Y., S.E. Tollefsen, and S. Kornfeld (1988) The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II. Journal of Biological Chemistry 263:2585–2588.
Waheed, A., T. Braulke, U. Junghans, and K. von Figura (1988) Mannose 6-phosphate/insulin like growth factor II receptor: the two types of ligands bind simultaneously to one receptor at different sites. Biochemical &Biophysical Research Communications 152:1248–54
Rechler, M.M., and S.P. Nissley (1985) The nature and regulation of the receptors for insulin-like growth factors. Annual Review of Physiology 47:425–442.
Lenoir, D., and P. Honegger (1983) Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures. Brain Research 283:205–213.
Enberg, G., A. Tham, and V.R. Sara (1985) The influence of purified somatomedins and insulin on foetal rat brain DNA synthesis in vitro. Acta Physiologica Scandinavica 125:305–308.
Yang, H.C., and A.B. Pardee (1986) Insulin-like growth factor I regulation of transcription and replicating enzyme induction necessary for DNA synthesis. Journal of Cellular Physiology 127:410–416.
Han, V.K., J.M. Lauder, and A.J. D’Ercole (1987) Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells. Journal of Neuroscience 7:501–511.
Shemer, J., M.K. Raizada, B.A. Masters, A. Ota, and D. LeRoith (1987) Insulin-like growth factor I receptors in neuronal and glial cells Characterization and biological effects in primary culture. Journal of Biological Chemistry 262:7693–7699.
Surmacz, E., L. Kaczmarek, O. Rnning, and R. Baserga (1987) Activation of the ribosomal DNA promoter in cells exposed to insulin-like growth factor I. Molecular &Cellular Biology 7:657–663.
DiCicco-Bloom, E., and I.B. Black (1988) Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts. Proc.Natl.Acad.Sci.USA 85:4066–4070.
Ota, A., Z. Shen-Orr, and D. LeRoith (1989) Insulin and IGF-I receptors in neuroblastoma cells: increases in mRNA and binding produced by glyburide. Neuropeptides 14: 171–175.
Aizenman, Y., J. de Vellis (1987) Brain neurons develop in a serum and glial free environment: Effects of transferrin, insulin, insulin-like growth factor-1 and thyroid hormone on neuronal survival, growth, and differentiation. Brain Research 406:32–42.
McMorris, F.A., T.M. Smith, S. DeSalvo, and R.W. Furlanetto (1986) Insulin-like growth factor l/somatomedin C: a potent inducer of oligodendrocyte development. Proc.Natl.Acad.Sci.USA 83:822–826.
McMorris, F.A., and M. Dubois-Dalcq (1988) Insulin-like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro. Journal of Neuroscience Research 21:199–209.
Mozell, R.L., and F.A. McMorris (1988) Insulin-like growth factor-l stimulates regeneration of oligodendrocytes in vitro. Annals of the New York Academy of Sciences 540:430–432.
Saneto, R.P., K.G. Low, M.H. Melner, and J. de Vellis (1988) Insulin/insulin-like growth factor I and other epigenetic modulators of myelin basic protein expression in isolated oligodendrocyte progenitor cells. Journal of Neuroscience Research 21:210–219.
van der Pal R.H., J.W. Koper, L.M. van Golde, and M. Lopes-Cardozo (1988) Effects of insulin and insulin-like growth factor (IGF-I) on oligodendrocyte-enriched glial cultures. Journal of Neuroscience Research 19:483–490.
Araujo, D.M., P.A. Lapchak, B. Collier, J.G. Chabot, and R. Quirion (1989) Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system. Brain Research 484:130–138.
Nilsson, L., V.R. Sara, and A. Nordberg (1988) Insulin-like growth factor 1 stimulates the release of acetylcholine from rat cortical slices. Neuroscience Letters 88:221–226.
Knusel, B., P.P. Michel, J.S. Schwaber, and F. Hefti (1990) Selective and Nonselective Stimulation of Central Cholinergic and Dopaminergic Development Invitro by Nerve Growth Factor, Basic Fibroblast Growth Factor, Epidermal Growth Factor, Insulin and the Insulin-Like Growth Factor-1 and Factor-ll. Journal of Neuroscience 10:558–570.
Tannenbaum, G.S., H.J. Guyda, and B.I. Posner (1983) Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain. Science 220:77–79.
Ceda, G.P., R.G. Davis, R.G. Rosenfeld, and A.R. Hoffman (1987) The growth hormone (GH)-releasing hormone (GHRH)-GH-somatomedin axis: evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors I and II. Endocrinology 120:1658–1662.
Yamashita, S., and S. Melmed (1987) Insulinlike growth factor I regulation of growth hormone gene transcription in primary rat pituitary cells. Journal of Clinical Investigation 79:449–452.
Bothwell, M. (1982) Insulin and somatomedin MSA promote nerve growth factor-independent neurite formation by cultured chick dorsal root ganglionic sensory neurons. Journal of Neuroscience Research 8:225–231.
Recio-Pinto, E., and D.N. Ishii (1984) Effects of insulin, insulin-like growth factor-ll and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells. Brain Research 302:323–334.
Mill, J.F., M.V. Chao, and D.N. Ishii (1985) Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation. Proc.Natl.Acad. Sci.USA 82:7126–7130.
Recio-Pinto, E., and D.N. Ishii (1988) Insulin and insulinlike growth factor receptors regulating neurite formation in cultured human neuroblastoma cells. Journal of Neuroscience Research 19:312–320.
Recio-Pinto, E., Rechler, M.M., Ishii, D.N., Effects of insulin-like growth factor-ll, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons. Journal of Neuroscience 6:1211–1219, (1986).
Marchand, C.M-F., S.P. Hunt, J. Schmidt (1979) Putative acetylcholine receptors in hippocampus and corpus striatum of rat and mouse. Brain Research 160:363–7.
Marks, M.J., J.A. Stitzel, E. Romm, J.M. Wehner, A.C. Collinis (1986) Nicotinic binding sites in rat and mouse: comparison of acetylcholine, nicotine and a-bungarotoxin. Molecular Pharmacology 30:427–36.
Fredens, K., K. Stengaard-Pedersen, M.N. Wallace (1987) Localization of cholecystokinin in the dentate commissural-associational system of the rat and mouse. Brain Research 401:68–78.
Palacios, J.M., D. Hoyer, R. Cortes (1987) α1-Adrenoceptors in the mammalian brain: similar pharmacology but different distribution in rodents and primates. Brain Research 419:65–75.
Dietl, M.M., J.M. Palacios (1989) Distribution of cholecystokinin receptors in vertebrate brain: Species differences studied by receptor autoradiography. J. Chemical Neuroanatomy 2:149–61.
West, M.J., A.H. Andersen (1980) An allometric study of the area dentata in the rat and mouse. Brain Res. Reviews 2:317–48.
Kishi, K., B.B. Stanfield, W.M. Cowan (1979) A note on distribution of glial cells in the molecular layer of the dentate gyrus. Brain Res. Bull. 4:35-41. p73
Sara, V.R., C. Carlsson-Skwirut, C. Andersson, E. Hall, B. Sjogren, A. Holmgren, and H. Jornvall (1986) Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I. Proc.Natl.Acad.Sci.USA 83:4904–4907.
Carlsson-Skwirut, C., M. Lake, M. Hartmanis, K. Hall, and V.R. Sara (1989) A comparison of the biological activity of the recombinant intact and truncated insulin-like growth factor 1 (IGF-1). Biochimica Et Biophysica Acta 1011:192–197.
Sara, V.R.,C. Carlsson-Skwirut,T. Bergman,H. Jornvall, P.J. Roberts, M. Crawford, L.N. Hakansson, I. Civalero, and A. Nordberg (1989) Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide. Biochemical &Biophysical Research Communications 165:766–771.
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© 1991 Plenum Press, New York
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Breese, C.R., D’Costa, A., Booze, R.M., Sonntag, W.E. (1991). Distribution of Insulin-Like Growth Factor 1 (IGF-1) and 2 (IGF-2) Receptors in the Hippocampal Formation of Rats and Mice. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_40
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DOI: https://doi.org/10.1007/978-1-4684-5949-4_40
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