IGF-I mRNA Localization in Trigeminal and Sympathetic Nerve Target Zones During Rat Embryonic Development

  • Carolyn Bondy
  • Edward Chin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)

Abstract

In recent years evidence has accumulated suggesting that insulin-like growth factors may have significant autocrine or paracrine roles in regulating the rate of growth or state of differentiation of various types of normal and tumorous tissue (1,2). A paracrine/autocrine role for insulin-like growth factor-l (IGF-I) in embryonic development has been suggested by the following observations. IGF-I is secreted by cultured fetal cells and explants and binds to specific receptors in fetal tissue (3,4). IGF-I immunoreactivity is low in fetal serum (5) but both IGF-I immunoreactivity and mRNA are detected in fetal tissues during the course of gestation (6-11). The presence of the type-l IGF receptor during embryogenesis has been demonstrated by binding studies (12,13) and by detection of receptor mRNA (11,14).

Keywords

Tyrosine Retina Hematoxylin Eosin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Underwood, L.E., D’Ercole, A.J., Clemmons, D.R. and Van Wyk, J.J. (1986) Paracrine functions of somatomedins. Clinics in Endocrinology and Metabolism 15:59–77.PubMedCrossRefGoogle Scholar
  2. 2.
    Daughaday, W. (1990) Editorial: The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors. Endocrinology 127:1–4.PubMedCrossRefGoogle Scholar
  3. 3.
    Underwood, L.E. and D’Ercole, A.J. (1984) Tissue growth factors. Clinics in Endocrinology and Metabolism 13:69–89.PubMedCrossRefGoogle Scholar
  4. 4.
    D’Ercole, A.J. and Underwood, L.E. (1986) in: Human GrowthFaulkner, F. & Tanner, J.M.,Vol. I, pp. 327–338, Plenum Publishing Co, New York.CrossRefGoogle Scholar
  5. 5.
    Daughaday, W.H., Parker, K.A., Borowsky, S., Trivedi, B. and Kapadia, M. (1982) Measurement of somatomedin-related peptides in fetal, neonatal and maternal rat serum. Endocrinology 110:575–581.Google Scholar
  6. 6.
    D’Ercole, A.J., Hill, D.J., Strain, L.E. and Underwood, L.E. (1986) Pediatric Res. 20:253–258.CrossRefGoogle Scholar
  7. 7.
    Lund, P.K., Moats-Staats, B.M., Hynes, M.A., Simmons, J..G, Jansen, M., D’Ercole, A.J.Van Wyk, J.J. (1986) Somatomedin-C/insulin-like growth factor-l and insulin-like growth factor-ll mRNAs in rat fetal and adult tissues. J. Biol. Chem. 261:14539–14544.PubMedGoogle Scholar
  8. 8.
    Han, V.K., D’Ercole, A.J., and Lund, P.K. (1987) Cellular localization of somatomedin (insulin-like growth factor) mRNA in the human fetus. Science 286:193–196.CrossRefGoogle Scholar
  9. 9.
    Rotwein, P., Burgess, S.K., Milbrandt, J.D. and Krause, J.E. (1988) Differential expression of insulin-like growth factor genes in rat central nervous system. Proc. Natl. Acad. Sci. 85:265–268.PubMedCrossRefGoogle Scholar
  10. 10.
    Beck, F., Samani, N.J., Penschow, J. D., Thorley, B., Tregear, G.W. and Coghlan, J.P. (1987) Histochemical localization of IGF-I and -II mRNA in the developing rat embryo. Dev. 101:175–184.Google Scholar
  11. 11.
    Bondy, C.A., Werner, H., Roberts, C.T., Jr., and LeRoith, D. (1990) Cellular pattern of IGF-I and Type I IGF receptor gene expression in organogenesis: comparison with IGF-II gene expression. Molec. Endocrinol. 4:1386–1398.CrossRefGoogle Scholar
  12. 12.
    Girbau, M., Bassas, L., Alemany, J. and de Pablo, F. (1989) In situ autoradiography and ligand-dependent tyrosine kinase activity reveal insulin receptors and insulin-like growth factor receptors in prepancreatic chicken embryos. Proc. Natl. Acad. Sci. USA 86:5868–5872.PubMedCrossRefGoogle Scholar
  13. 13.
    Mattson, B.A., Rosenblum, I.Y., Smith, R.M. and Heyner, S. (1988) Autoradiographic evidence for insulin and insulin-like growth factor binding to early mouse embryos. Diabetes 37:585–589.PubMedCrossRefGoogle Scholar
  14. 14.
    Werner, H., Woloschek, M., Adamo, M., Shen-Orr, Z., Roberts, C.T., Jr., and LeRoith, D. (1989) Developmental regulation of the rat IGF-I receptor gene. Proc. Natl. Acad. Sci. 86:7451–7455.PubMedCrossRefGoogle Scholar
  15. 15.
    Erzurumlu, R.S. and Killackey, H.P. (1983) Development of order in the rat trigeminal system. J. Comp. Neurol. 213:365–380.PubMedCrossRefGoogle Scholar
  16. 16.
    Recio-Pinto, E. and Ishii, D.N. (1988) Insulin and related growth factors: Effects on the nervous system and mechanism for neurite growth. Neurochem. Int. 12:397–414.PubMedCrossRefGoogle Scholar
  17. 17.
    Davies, A.M., Bandtlow, C., Heumann, R., Korsching, S., Roher, H. and Thoenen, H. (1987) Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor. Nature326:353–358.PubMedCrossRefGoogle Scholar
  18. 18.
    Shelton, D.L. and Reichardt, L.F. (1984) Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.Proc. Natl. Acad. Sci. 81:7951–7955.PubMedCrossRefGoogle Scholar
  19. 19.
    Heumann, R., Korsching, S., Scott, J. and Thoenen, H. (1984) Relationship of NGF and its mRNA in sympathetic ganglia and peripheral target tissues. EMBO 3:3183–3189.Google Scholar
  20. 20.
    Hansson, H.-A., Rozell, B. and Skottner, A. (1987) Rapid axoplasmic transport of insulin-like growth factor I in the sciatic nerve of adult rats. Cell Tissue Res. 247:241–247.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Carolyn Bondy
    • 1
  • Edward Chin
    • 1
  1. 1.Developmental Endocrinology Branch National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaUSA

Personalised recommendations