Early Events in the Hormonal Regulation of Glial Gene Expression: Early Response Genes

  • Alaric Arenander
  • Janet Cheng
  • Jean de Vellis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)


Glial cells play important roles in the development arid the functioning of the brain (Arenander and de Vellis, 1983, Arenander and de Vellis, 1989). Glial cell development and functions are regulated by growth factors, hormones, neurotransmitters and other autocrine and paracrine factors and cell-cell contact. How are these factors mediating their effects? The diversity of cell types and complexity of cellular interaction necessitated developing in vitro methods to study mechanisms of glial growth and function. Cell culture techniques allow experimental control of developmental events and molecular markers allow precise identification of cell types. As a result, glial research has greatly advanced our understanding of the molecular and cellular mechanisms regulating neural development.


Glial Cell PC12 Cell Nerve Growth Factor Early Response Gene Serum Response Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Alaric Arenander
    • 1
  • Janet Cheng
    • 1
  • Jean de Vellis
    • 1
  1. 1.Department of Anatomy and Cell Biology, Mental Retardation Research Center, NPIUCLA School of MedicineLos AngelesUSA

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