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Characterization of the Biological Activity of IGF I Analogs with Reduced Affinity for IGF Receptors and Binding Proteins

  • Margaret A. Cascieri
  • Gary G. Chicchi
  • Marvin L. Bayne
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)

Abstract

We have prepared a series of IGF I analogs in order to determine the structural requirements for binding to the types 1 and 2 IGF receptors and to IGF binding proteins (1-5). These analogs were designed by substituting regions of IGF I with analogous regions of insulin, by deleting or replacing regions of IGF I that are absent in insulin, or by replacing specific residues of IGF I. The binding data for these analogs is summarized in Table 1.

Keywords

Biological Potency Placental Membrane Normal Affinity Disuccinimidyl Suberate Dohme Research Laboratory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Margaret A. Cascieri
    • 1
  • Gary G. Chicchi
    • 1
  • Marvin L. Bayne
    • 1
  1. 1.Departments of Biochemical Endocrinology and Growth Factor ResearchMerck Sharp & Dohme Research LaboratoriesRahwayUSA

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