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Expression of IGF-II, the IGF-II/Mannose-6-Phosphate Receptor and IGFBP-2 During Rat Embryogenesis

  • John E. Pintar
  • Teresa L. Wood
  • Randal D. Streck
  • Leif Havton
  • Leslie Rogler
  • Ming-Sing Hsu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)

Abstract

It is becoming increasingly apparent that the IGF system (including both IGF-I and IGF-II, at least two IGF receptors, and a family of at least six IGF binding proteins; 1-3) has a fundamental role in the normal progression of prenatal development. The initial observation that IGF-II peptide levels were high in the fetus but decreased post-natally (4) was the first to suggest that this peptide might have functional importance during ontogeny. In situ hybridization studies (5-7) extended Northern analysis and confirmed that the developmental regulation of IGF-II expression extends to the level of RNA regulation and demonstrated that the IGF-II gene expression pattern during ontogeny is precisely regulated both temporally and spatially. These results suggested that if the autocrine-paracrine mode of action classically proposed for the IGFs (1,2) was in fact correct, then interference with normal IGF-II synthesis would be expected to produce regional rather than systemic deficits.

Keywords

Apical Ectodermal Ridge Surface Ectoderm Hyoid Arch Nasal Placode Embryonic Epiblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • John E. Pintar
    • 1
  • Teresa L. Wood
    • 1
  • Randal D. Streck
    • 1
  • Leif Havton
    • 1
  • Leslie Rogler
    • 1
  • Ming-Sing Hsu
    • 1
  1. 1.Department of Anatomy and Cell Biology Centers for Reproductive Science and Neurobiology and BehaviorColumbia University College of Physicians and SurgeonsNew YorkUSA

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