Expression of IGF-II, the IGF-II/Mannose-6-Phosphate Receptor and IGFBP-2 During Rat Embryogenesis

  • John E. Pintar
  • Teresa L. Wood
  • Randal D. Streck
  • Leif Havton
  • Leslie Rogler
  • Ming-Sing Hsu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)


It is becoming increasingly apparent that the IGF system (including both IGF-I and IGF-II, at least two IGF receptors, and a family of at least six IGF binding proteins; 1-3) has a fundamental role in the normal progression of prenatal development. The initial observation that IGF-II peptide levels were high in the fetus but decreased post-natally (4) was the first to suggest that this peptide might have functional importance during ontogeny. In situ hybridization studies (5-7) extended Northern analysis and confirmed that the developmental regulation of IGF-II expression extends to the level of RNA regulation and demonstrated that the IGF-II gene expression pattern during ontogeny is precisely regulated both temporally and spatially. These results suggested that if the autocrine-paracrine mode of action classically proposed for the IGFs (1,2) was in fact correct, then interference with normal IGF-II synthesis would be expected to produce regional rather than systemic deficits.


Apical Ectodermal Ridge Surface Ectoderm Hyoid Arch Nasal Placode Embryonic Epiblast 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • John E. Pintar
    • 1
  • Teresa L. Wood
    • 1
  • Randal D. Streck
    • 1
  • Leif Havton
    • 1
  • Leslie Rogler
    • 1
  • Ming-Sing Hsu
    • 1
  1. 1.Department of Anatomy and Cell Biology Centers for Reproductive Science and Neurobiology and BehaviorColumbia University College of Physicians and SurgeonsNew YorkUSA

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