Insulin-Like Growth Factor Receptors in Testicular Vascular Tissue from Normal and Diabetic Rats

  • Joyce F. Haskell
  • Russell B. Myers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)


The complex endocrine regulation of the testicular vascular system is ill defined. Many blood vessels contain growth factor receptors, including those for insulin, IGF-I, and IGF- II. These growth factors may interact to modulate growth and/or repair of damaged vessels, and possibly regulate blood vessel permeability and responsiveness to other regulatory substances. Diabetic vascular complications have many common features whether large or small blood vessels are involved. Whether growth hormone or other growth factors are involved in the altered vascular cell proliferation, thickening of the basement membrane and altered vascular permeability is not yet known. Retinopathy, peripheral vascular disease and glomerular nephropathy remain frequent diabetic abnormalities. Male reproductive functions are also commonly compromised in diabetics. Impotency and decreased androgen levels may result from vascular complications, in addition to diabetic neuropathy. In the present study, we examined insulin-like growth factor receptor characteristics from normal and diabetic testicular vascular tissue using immunohistochemical and affinity crosslinking techniques.


Leydig Cell Testicular Artery Diabetic Vascular Complication Male Reproductive Function Testicular Vessel 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Joyce F. Haskell
    • 1
  • Russell B. Myers
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of Alabama at BirminghamBirminghamUSA

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