Insulin-Like Growth Factors and Their Receptors in Muscle Development

  • Gyorgyi Szebenyi
  • Peter Rotwein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)


Insulin-like growth factors (IGF) I and II exert pleiotropic actions on target tissues. In muscle both IGF-I and II exhibit a range of physiological effects, including a concentration-dependent stimulation of metabolic functions such as glucose and amino acid uptake, acceleration of the rate of DNA synthesis, and enhancement of myoblast differentiation (1-4). The mitogenic and metabolic effects of the IGFs can be distinguished from their differentiation-promoting properties: the stimulation of differentiation persists in the presence of inhibitors of cell replication (5,6), and antisense myogenin oligonucleotides, which block IGF-l-induced differentiation, do not influence IGF-I stimulated metabolite uptake or proliferation (7). These observations imply that distinct signal-transduction pathways may be involved in each process.


Lysosomal Enzyme Myoblast Differentiation Lysosomal Glycosidase Terminal Myogenic Differentiation Inositol Phosphate Turnover 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Gyorgyi Szebenyi
    • 1
  • Peter Rotwein
    • 1
  1. 1.Departments of Medicine and Genetics Division of Biology and Biomedical ScienceWashington University School of MedicineSt. LouisUSA

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