Molecular Heterogeneity of Insulin Receptors in Rat Tissues
Heterogeneity in the structure and function of the insulin receptor in various tissues and animal species has recently been reported by several laboratories. Our laboratory has been interested in determining the molecular basis for this variation in the insulin receptor, which may be involved in the regulation of certain actions of insulin in target cells. This brief presentation will summarize our recent work in this area which has used a variety of molecular approaches to study the structure of the coding region of insulin receptor mRNA transcripts in several rat tissues.
KeywordsInsulin Receptor Insulin Receptor Gene Human Insulin Receptor Insulin Receptor mRNA Brain Insulin Receptor
Unable to display preview. Download preview PDF.
- 6.A. Ullrich, J.R. Bell, E.Y. Chen, R. Herrera, L.M. Petruzzelli, T.J. Dull, A. Gray, L. Coussens, Y-C. Liao, M. Tsubokawa, A. Mason, P.H. Seeburg, C. Grunfeld, O.M. Rosen, and J. Ramachandran, Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes, Nature 313:756 (1985).PubMedCrossRefGoogle Scholar
- J.L. Gu, R.M. Shymko, B. Wallach, J. Whittaker, and P. De Meyts, Receptor binding properties of the two natural variants of the insulin receptor, Diabetes 39:79A (1990).Google Scholar