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Regulation of Gene Expression of Rat Insulin-Like Growth Factor Binding Proteins 1 and 2

  • Matthew M. Rechler
  • Alexandra L. Brown
  • Guck T. Ooi
  • Craig C. Orlowski
  • Lucy Y.-H. Tseng
  • Yvonne W.-H. Yang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)

Abstract

Virtually all of the insulin-like growth factors (IGFs) in extracellular fluids and cell culture medium occur complexed to specific IGF-binding proteins (IGFBPs).1,2 The IGFBPs are a family of proteins that bind IGF-I and IGF-II but are unrelated to IGF receptors. Four IGFBPs have been cloned from human and rat sources,1–8 and partial protein sequence information is available forafifthlGFBP.9–11 OthermembersoftheIGFBPfamilyundoubtedlyexist,12butspecific assignment must await amino acid or nucleotide sequencing.

Keywords

Growth Hormone Human Cerebrospinal Fluid Binding Protein Complex Human Lung Fibroblast Cell Line Insulin Response Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Matthew M. Rechler
    • 1
  • Alexandra L. Brown
    • 1
  • Guck T. Ooi
    • 1
  • Craig C. Orlowski
    • 1
  • Lucy Y.-H. Tseng
    • 1
  • Yvonne W.-H. Yang
    • 1
  1. 1.Growth and Development Section, Molecular, Cellular and Nutritional Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney DiseaseNational Institutes of HealthBethesdaUSA

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