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Single sc Administration of Insulin-Like Growth Factor I (IGF-I) in Normal Men

  • Naomi Hizuka
  • Kazue Takano
  • Kumiko Asakawa
  • Izumi Fukuda
  • Izumi Sukegawa
  • Kazuo Shizume
  • Hiroshi Demura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)

Abstract

Insulin-like growth factor I (IGF-I) has been synthesized by recombinant DNA technology (1). With the availability of large quantities of the biosynthetic peptide, the biological effects have been studied in animals in vivo. We have previously reported that IGF-I has growth promoting, anabolic, and insulin-like effects in hypophysectomized and normal rats, and IGF-I inhibits catabolism in fasted rats in vivo (2–5). Recently, the biological effects of IGF-I have been studied in normal men and patients with Laron-type dwarfism (6–9). We have also studied effects of IGF-I single sc administration in normal men (10). In this paper, the results of the single sc administration of IGF-I combined with our previous data (10) are reported.

Keywords

Growth Hormone Growth Hormone Secretion Decrease Blood Glucose Level Urinary Urea Nitrogen Urinary Growth Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Niwa M, Sato S, Saito Y, Uchiyama F, Ono H, Yamashita M, Kitaguchi Y, Shiga Y, Notani J, Yamada H, Ishii Y, Ueda I and Takagi Y. Chemical synthesis, cloning, and expression of genes for human somatomedin C (insulin-like growth factor I) and 59Val-somatomedin C. Ann NY Acad Sci 469:31–52 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    Hizuka N, Takano K, Shizume K, Asakawa K, Miyakawa M, Tanaka I and Horikawa R. Insulin-like growth factor I stimulates growth in normal growing rats. Eur J Phamacol 125:U3–U6 (1986).CrossRefGoogle Scholar
  3. 3.
    Hizuka N, Takano K, Asakawa K, Miyakawa M, Tanaka I, Horikawa R, Hasegawa S, Mikasa Y, Saito S, Shibasaki T and Shizume K. In vivo effects of insulin-like growth factor I in rats. Endocrinol Japon 34(Suppl):115–121 (1987).CrossRefGoogle Scholar
  4. 4.
    Hizuka N, Takano K, Asakawa K, Sukegawa I, Horikawa R, Kikuchi H and Shizume K. Biological action of insulin-like growth factor-I in vivo. In: Bercu BB (ed) Basic and Clinical Aspects of Growth Hormone Plenum Press New York p. 223–231 (1988).Google Scholar
  5. 5.
    Hizuka N, Takano K, Asakawa K, Shizume K and Kikuchi H. Biological effects of insulin-like growth factor I in vivo. Gunma Symposia on Endocrinology 25:137–U7 (1988).Google Scholar
  6. 6.
    Guler H-P, Zapf J and Froesch ER. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N Engl J Med 317:137–140 (1987).PubMedCrossRefGoogle Scholar
  7. 7.
    Guler H-P, Schmid C, Zapf J and Froesch ER. Effects of recombinant IGF-I on insulin secretion and renal function in normal human subjects. Proc Natl Acad Sci USA 86:2868–2872 (1989).PubMedCrossRefGoogle Scholar
  8. 8.
    Guler H-P, Eckardt K-U, Zapf J, Bauer C and Froesch ER. Insulin-like growth factor I increases glomerular filtration rate and renal plasma flow in man. Acta Endocrinol 121:101–106 (1989).PubMedGoogle Scholar
  9. 9.
    Laron Z, Klinger B, Ersner B and Anin S. Effects of acute administration of insulin-like growth factor I in patients with Laron-type dwarfism. Lancet II 1170–1172 (1988).CrossRefGoogle Scholar
  10. 10.
    Takano K, Hizuka N, Asakawa K, Sukegawa I, Shizume K and Demura H. Effects of sc administration of recombinant human insulin-like growth factor I (IGF-I) on normal human subjects. Endocrinol Japon 37:309–317 (1990)CrossRefGoogle Scholar
  11. 11.
    Miyakawa M, Hizuka N, Takano K, Tanaka I, Horikawa R, Honda N and Shizume K. Radioimmunoassay for insulin-like growth factor I (IGF-I) using biosynthetic IGF-I. Endocrinol Japon 33:795–801 (1986).CrossRefGoogle Scholar
  12. 12.
    Daughaday WH, Mariz IK and Blethen SK. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol-extracted serum. J Clin Endocrinol Metab 51:781–788 (1980).PubMedCrossRefGoogle Scholar
  13. 13.
    Hizuka N, Takano K, Asakawa K, Sukegawa I, Fukuda I, Demura H, Iwashita M, Adachi T and Shizume K. Measurement of free form of insulin-like growth factor I in human plasma. Growth Regulation submitted.Google Scholar
  14. 14.
    Asakawa K, Hizuka N, Takano K, Fukuda I, Sukegawa I, Demura H and Shizume K Radioimmunoassay for insulin-like growth factor II (IGF-II). Endocrinol Japon 37:in press (1990).Google Scholar
  15. 15.
    Sukegawa I, Hizuka N, Takano K, Asakawa K, Horikawa R, Hashida S, Ishikawa E, Mohri Z, Murakami Y and Shizume K. Urinary growth hormone (GH) measurements are useful for evaluating endogenous GH secretion. J Clin Endocrinol Metab 66:1119–1123 (1988).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Naomi Hizuka
    • 1
  • Kazue Takano
    • 1
  • Kumiko Asakawa
    • 1
  • Izumi Fukuda
    • 1
  • Izumi Sukegawa
    • 1
  • Kazuo Shizume
    • 2
  • Hiroshi Demura
    • 1
  1. 1.Department of MedicineTokyo Women’s Medical CollegeTokyo, 162Japan
  2. 2.Research LaboratoryFoundation for Growth ScienceTokyo, 162Japan

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