Alcoholism pp 89-93 | Cite as

Ethanol-Induced Phosphorylation of Cytokeratins in Primary Cultured Hepatocytes

  • Samuel W. French
  • H. Kawahara
  • M. Cadrin
Part of the NATO ASI Series book series (NSSA, volume 206)


Phosphorylation of specific proteins by protein kinase A (PKA) or protein kinase C (PKC) may play a role in the regulation of assembly and disassembly and stability of intermediate filaments including intermediate filaments composed of cytokeratins (CKs). Initiation of the phosphorylation is through signal transduction by agonist receptor G protein activation of a catalyst such as cyclic AMP or phospholipase C which activate PKA or PKC, respectively.


Intermediate Filament Phorbol Ester Fibronectin Coated Dish Epithelial Amnion Cell Cytokeratin Protein 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Samuel W. French
    • 1
  • H. Kawahara
    • 1
  • M. Cadrin
    • 1
  1. 1.Department of Pathology Faculty of MedicineUniversity of OttawaOttawaCanada

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