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Alcoholism pp 45-56 | Cite as

Free Radical Mediated Reactions and Ethanol Toxicity: Some Considerations on the Methodological Approaches

  • Emanuelle Albano
  • Magnus Ingelman-Sundberg
  • A. Tomasi
  • G. Poli
Part of the NATO ASI Series book series (NSSA, volume 206)

Abstract

In the last few years the occurrence of free radical-mediated reactions, including lipid peroxidation, as a result of ethanol intoxication have received new attention, and it is now generally accepted that oxidative damages might play a role in the pathogenesis of tissue damage due to alcohol abuse (Lieber, 1988). Nonetheless, it should be realized that since the early work of Di Luzio, who first suggested an involvement of lipid peroxidation in causing liver lesions following ethanol poisoning (Di Luzio and Hartman, 1967; Comporti et al., 1967), this topic has been a matter of a long standing debate. The main reason of such a controversy is the fact that the results obtained in different laboratories have often been contradictory because of methodological differences (Videla and Valenzuela, 1982; Dianzani, 1985), and also because of the use of analytical techniques not always suitable for the detection of low levels of radical-associated tissue damage.

Keywords

Lipid Peroxidation Electron Spin Resonance Electron Spin Resonance Spectroscopy Chronic Ethanol Spin Trapping 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Emanuelle Albano
    • 1
    • 2
    • 3
  • Magnus Ingelman-Sundberg
    • 1
    • 2
    • 3
  • A. Tomasi
    • 1
    • 2
    • 3
  • G. Poli
    • 1
    • 2
    • 3
  1. 1.Dept. of Experimental Medicine and OncologyUniversity of TurinTurinItaly
  2. 2.Dept. of Physiological ChemistryKarolinska InstitutetStockholmSweden
  3. 3.Institute of General PathologyUniversity of ModenaModenaItaly

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