Advertisement

Alcoholism pp 309-316 | Cite as

Effect of Ethanol on Gastrointestinal Cell Proliferation

  • Ulrich A. Simanowski
  • Burkhard Kommerell
  • Helmut K. Seitz
Part of the NATO ASI Series book series (NSSA, volume 206)

Abstract

Cell proliferation is an important measure and characteristic of tissues. Its evaluation must be quantitative as well as morpological, relating proliferative activity to histological structure. Cell proliferation is dynamic, measurement of it should include time, moreover it can even change with time. Therefore, one time point measurements are always equivocal, and even observations over time must neglect acceleration or slowing of proliferative activity, unless experiments are tremendous laborious with multiple time point observations.

Keywords

Chronic Ethanol Colostomy Closure Alcoholic Fatty Liver Chronic Ethanol Consumption Chronic Ethanol Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baraona, E., Pirola, R.C. and Lieber, C.S., 1974. Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat. Gastroenterology 66: 226–34.Google Scholar
  2. Barthold, S.W. and Jonas, A.M., 1977. Morphogenesis of early 1,2dimethylhydrazineinduced lesions and latent period of colon carcinogenesis in mice by a variant of Citrobacter freundii. Cancer Res., 37: 4352–60.Google Scholar
  3. Bristol, J., Wells, M. and Williamson, R.C.N., 1982. Jejunoileal bypass stimulates cell proliferation and enhances experimental carcinogenesis in the rat large bowel. (abstr.) Proc Am Assoc Cancer Res., 23: 233.Google Scholar
  4. Bleiberg, H., Mainguet, P., Galant, P., Chretiell, J. and Dupont-Marisse, N., 1970. Cell renehal in the human rectum; in vitro autoradiographic study on active ulcerative colitis. Gastroenterology 58: 851–5.PubMedGoogle Scholar
  5. Chen, T., Kiernan, T. and Leevy, C.M., 1981. Ethanol and cell replication in the digestive tract. Clinics in Gastroenterology 10: 343–54.PubMedGoogle Scholar
  6. Cleveland, J.C., Litvak, S.F. and Cole, J.W., 1967. Identification of the route of action of the carcinogen 3,2-dimethyl-aminobiphenyl in the induction of intestinal metaplasia. Cancer Res., 27: 708–12.Google Scholar
  7. Cohen, B.I., Raicht, R.F., Deschner, E.E., Takahashi, M., Sarwal, A.N. and Fazzini, E., 1980. Effect of cholic acid feeding on N-methyl-N-nitrosourea-induced colon tumors and cell kinetics in rats. JNCI., 64: 573–8.Google Scholar
  8. Collins, R.H., Feldman, M. and Fordtran, J.S., 1987. Colon cancer, dysplasia, and surveillance in patients with ulcerative colitis; a critical review. N Engl J Med., 316: 1654–8.Google Scholar
  9. Gennaro, A.R., Villaneauva, R., Sukon-Haman, Y., Vathanphas, V. and Rosemond, G.P., 1973. Chemical carcinogenesis in transposed intestinal segments. Cancer Res., 33: 536–41.Google Scholar
  10. Goodlad, R.A. and Wright, N.A., 1982. Quantitative studies on epithelial replacement in the gut. In: Titchell, D.A. (ed) Techniques in the life sciences. Digestive physiology. County Clare: Elsevier Biomedical, 1–23.Google Scholar
  11. Gottfried, E.B., Korsten, N.M.A. and Lieber, C.S., 1978. Alcohol induced gastric and duodenal lesions in man. Amer J Gastroenterol., 70: 578–92.Google Scholar
  12. Haentjens, P., DeBaker, A. and Willems, G., 1987. Effect of an apple brandy from Normandy and of ethanol on epithelial cell proliferation in the esophagus of rats. Digestion 37: 184–92.PubMedCrossRefGoogle Scholar
  13. Halsted, C.H., Robles, E.A. and Mezey, E., 1973. Distribution of ethanol in the human gastrointestinal tract. Am J Clin Nutr., 26: 831–4.Google Scholar
  14. Holt, P.R. and Yeh, K.-y., 1988. Colonic proliferation is increased in senescent rats. Gastroenterology 95: 1556–63.PubMedGoogle Scholar
  15. Holt, P.R. and Yeh, K.-y., 1989. Small intestinal crypt cell proliferation rates are increased in senescent rats. J Gerontol., 44: B9–11.Google Scholar
  16. Iishi, H., Tatsuta, M., Baba, M. and Taniguchi, H., 1989. Promotion by ethanol of gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in Wistar rats. Br J Cancer., 59: 719–21.Google Scholar
  17. Kikendall, J.W., Bowen, P.E., Burgess, M.B., Magnetti, C., Woodward, J. and Langenberg, P. 1989. Cigarettes and alcohol as independent risk factors for colonic adenomas. Gastroenterology 97: 660–4.PubMedGoogle Scholar
  18. Kvietys, P.R., Twohig, B., Danzell, J. and Specian, R.D., 1990. Ethanol-induced injury to the rat gastric mucosa. Gastroenterology 98: 909–20.PubMedCrossRefGoogle Scholar
  19. Lev, R., Thomas, E., Parl, F.F. and Pitchumoni, C.S., 1980. Pathological and histomorphometric study of the effects of alcoholic fatty liver. Am J Clin Nutr., 23: 474–8.Google Scholar
  20. Lieber, C.S. and DeCarli, L.M., 1970. Quantitative relationship between the amount of dietary fat and the severity of alcoholic fatty liver. Am J Clin Nutr., 23: 474–8.PubMedGoogle Scholar
  21. Lipkin, M., 1981. Early identification of population groups at high risk for gastrointestinal cancer. In: Malt, R.A., Williamson, R.C.N., (eds) Colonic carcinogenesis. MTP Press, Lancaster, 31–46.Google Scholar
  22. Lipkin, M., 1984. Method for binary classification and risk; assessment of individuals with familial polyposis based on 3H-TdR labelling of epithelial cells in colonic crypts. Cell Tissue Kinet., 17: 209–22.Google Scholar
  23. Mak, K.M., Leo, M.A. and Lieber, C.S. 1987. Effect of ethanol and vitamin A difficiency on epithelial cell proliferation and structure in the rat esophagus. Gastroenterology, 93: 362–70.PubMedGoogle Scholar
  24. Mazzanti, R. and Jenkins,W.J., 1984. Effect of chronic ethanol ingestion on enterocyte turnover in the small intestine. Abstract. British Society of Gastroenterology. Autumn Meeting.Google Scholar
  25. Mueller, P., Hepke, B., Meldau, U. and Raabe, G., 1983. Tissue damage in the rabbit oral mucosa by acute and chronic direct toxic action of different ethanol concentrations. Exp Pathol., 24: 171–81.Google Scholar
  26. Pollack, E.S., Nomura, A.M.Y., Heilbrun, L.K., Stemmermann, G.N. and Green, S.B. 1984. Prospective study of alcohol consumption and cancer. N Engl J Med., 310: 617–21.Google Scholar
  27. Pozharisski, K.M., 1975. Morphology and morphogenesis of experimental epithelial tumors of the intestine. JNCI., 54: 111–535.Google Scholar
  28. Roe, R., Fermor, B. and Williamson, R.C.N., 1987. Proliferative instability and experimental carcinogenesis at colonic anastomoses. Gut 28: 808–15.Google Scholar
  29. Rosenberg, I.H. and Mason, J.B., 1989. Folate, dysplasia, and cancer. Gastroenterology 97: 5023.Google Scholar
  30. Rubin, E., Rybak, B.J., Lindenbaum, J., Gerson, C.D., Walker, G. and Lieber, C.S., 1972. Ultrastructural changes in the small intestine induced by ethanol. Gastroenterology 63: 801–14.Google Scholar
  31. Rubio, C.A., 1980. Experimental colon cancer in the absence of intestinal contents in Sprague Dawley rats. JNCI., 64: 569–72.Google Scholar
  32. Salaspuro, M. and Lindros, K., 1985. Metabolism and toxicity of acetaldehyde. In: Alcohol related diseases in gastroenterology. Seitz, H.K., Kommerell, B., eds., Springer Verlag, Berlin, Heidelberg.Google Scholar
  33. Seitz, H.K. and Simanowski, U.A., 1989. Ethanol and colorectal carcinogenesis. In: Seitz, H.K., Simanowski, U.A., Wright, N.A. (eds) Colorectal cancer. From pathogenesis to prevention. Springer, Berlin, 177–89.Google Scholar
  34. Seitz, H.K., Czygan, P. and Kommerell, B., 1982. Stimulation of thymidine incorporation in isolated rat intestinal mucosal cells by feeding an ethanol-containing liquid diet. Digestion 23: 65–7.PubMedCrossRefGoogle Scholar
  35. Seitz, H.K., Czygan, P., Kienapfel, H., Veith, S., Schmidt-Gayk, H. and Kommerell, B., 1983. Changes in gastrointestinal DNA synthesis produced by acute and chronic ethanol consumption in the rat: a biochemical study. Gastroenterology, 21: 79–84.Google Scholar
  36. Seitz, H.K., Czygan, P., Waldherr, R., Veith, S., Raedsch, R., Kaessmodel, H. and Kommerell, B., 1984. Enhancement of 1, 2-dimethylhydrazine-induced rectal carcinogenesis following chronic ethanol consumption in the rat. Gastroenterology, 86: 886–91.Google Scholar
  37. Seitz, H.K., Velasquez, D., Waldherr, R., Veith, S., Czygan, P., Weber, E., DeutschDiescller, O.G. and Kommerell, B., 1985. Duodenal gamma-glutamyltransferase activity in human biopsies: effect of chronic ethanol consumption and duodenal morphology. Eur J Clin Invest., 15: 1926.Google Scholar
  38. Seitz, H.K., Simanowski, U.A., Garzon, F.T., Rideout, J. M., Peters, Ti., Koch, A., Berger, M.R., Einecke, H. and Maiwald, M., 1990. Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. Gastroenterology 98: 406–13.PubMedGoogle Scholar
  39. Shaw, S., Jayatilleke, E., Herbert, V. and Colmann, N., 1989. Cleavage of folates during ethanol metabolism. Biochem J., 257: 277–80.Google Scholar
  40. Simanowski, U.A., Seitz, H.K., Baier, B., Kommerell, B., Schmidt-Gayk, H. and Wright, N.A., 1986. Chronic ethanol consumption selectively stimulates rectal cell proliferation in the rat. Gut 27: 278–82.PubMedCrossRefGoogle Scholar
  41. Simanowski, U.A., Suter, P., Russell, R.M., Seitz, H.K., 1990. Cell regeneration in the rat rectum after chronic ethanol ingestion is significantly enhanced with age. (abstr.) Alcoholism Clin Exp Res., 14: 338.Google Scholar
  42. Swinson, C.M., Salvin, G., Coles, E.C. and Booth, C.C., 1983. Celiac disease and malignancy. Lancet 1:11–1–5.Google Scholar
  43. Terpstra, O.T., Peterson Dahl, E., Williamson, R.C.N., Ross, J.S. and Malt, R.A., 1981. Colostomy closure promotes cell proliferation and dimethylhydrazine-induced carcinogenesis in rat distal colon. Gastroenterology 81: 475–80.PubMedGoogle Scholar
  44. Williamson, R.C.N., 1979. Hyperplasia and neoplasia of the intestinal tract. Ann R Coll Surg Engl., 61: 341–8.Google Scholar
  45. Williamson, R.C.N. and Malt, R.A., 1980. Promotion of intestinal carcinogenesis by adaptive mucosal hyperplasia. In: Appleton, D.R., Sunter, J.P. and Watson, A.J., (eds.) Cell proliferation in the gastrointestinal tract. Pitman, London, 303–15.Google Scholar
  46. Wittig, G., Wildner, G.P. and Zeibarth, D., 1971. Der Einfluss der Ingesta auf die Kanzerisierung des Rattendarmes durch Dimethylhydrazin. Arch Geschwulstforsch, 37: 105–15.PubMedGoogle Scholar
  47. Wright, N.A., Alison, M., 1984. The biology of epithelial cell populations. Clarendon, Oxford.Google Scholar
  48. Wright, N.A., Watson, A., Morley, A., Appleton, D. and Marks, J., 1973. Cell kinetics in flat avillous mucosa of the human small intestine. Gut 14: 701–10.PubMedCrossRefGoogle Scholar
  49. Wu, A.H., Paganini-Hill, A., Ross, R.K. and Henderson, B.E., 1987. Alcohol, physical activity and other risk factors for colorectal cancer: A prospective study. Br J Cancer., 55: 687–94.Google Scholar
  50. Zucoloto, S. and Rossi, M.A., 1979. Effect of chronic ethanol consumption on mucosal morphology and mitotic index in the rat small intestine. Digestion 19: 277–83.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Ulrich A. Simanowski
    • 1
  • Burkhard Kommerell
    • 1
  • Helmut K. Seitz
    • 1
  1. 1.Division of Gastroenterology Dept. of Internal MedicineUniversity of HeidelbergHeidelbergGermany

Personalised recommendations