Alcoholism pp 35-44 | Cite as

Free Radical Pathology in Alcohol-Induced Liver Injury

  • Mario Umberto Dianzani
Part of the NATO ASI Series book series (NSSA, volume 206)


Increasing importance is attributed to the damage provoked by free radicals during both acute and chronic alcohol-induced liver injury. The first insight into the problem came from the experiments by Di Luzio and Costales (1964), showing a protective action of antioxidants on fatty liver following acute ethanol treatment in the rat. As lipid peroxidation had been shown to increase in CC14-induced liver damage (Comporti et al., 1965; Recknagel and Ghoshal, 1966), Comporti et al. (1967) studied the behaviour of this parameter in ethanol-treated rats and found an increase in the production of malonyldialdehyde. Hashimoto et al.(1968), however, found no appearance of the diene conjugation band in microsomal lipids of treated rats. This started a long-standing controversy, that may be considered today as concluded by several demonstrations of increased lipid peroxidation after acute, and especially after chronic, treatment of rats (Diazani, 1985; Yamada et al., 1988). Clinical demonstration of increased lipid peroxidation in chronic alcoholics has been reported (Moscarella et al., 1984).


Lipid Peroxidation Xanthine Oxidase Ethanol Oxidation Ethanol Poisoning Adenylate Cyclase System 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Mario Umberto Dianzani
    • 1
  1. 1.Department of Experimental Medicine and Oncology Section of General PathologyUniversity of TurinTurinItaly

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