Metabolism of Ethanol and Higher Alcohols Present in Alcoholic Drinks and Their Corresponding Aldehydes in Sub-Cellular Components of Rat Esophageal Mucosa, and Relevance for Esophageal Cancer in Man
Esophageal cancer has one of the highest world-wide frequency rates for any form of cancer, exceeding that for liver (Parkin 1988). It is also one of the most rapidly fatal cancers and one of the most unpleasant. The geographical distribution is exceptionally well demarcated, a high incidence cancer belt running from Iran to China, with other high incidence areas in South Africa, in the Transkei, in Northern France, in Switzerland and in Scotland (Day et al 1982). While the etiology must differ in different localities, in Europe and USA by far the predominant cause is consumption of alcoholic beverages. Tobacco use has a synergistic effect, but in America at least 75% esophageal cancer was estimated to depend on alcohol consumption (Rothman 1980), and in France alcohol is a much more important cause than is tobacco (Tuyns 1982).
KeywordsEsophageal Cancer Alcohol Dehydrogenase Alcoholic Beverage Esophageal Mucosa High Incidence Area
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