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Alcoholism pp 253-267 | Cite as

Alcohol and Protein Turnover

  • Victor R. Preedy
  • Tahir Siddiq
  • Elisabeth Cook
  • Darcey Black
  • T. Norman Palmer
  • Timothy J. Peters
Part of the NATO ASI Series book series (NSSA, volume 206)

Abstract

Ethanol administration induces a variety of pathological responses which in many tissues are manifested as reductions in tissue protein content. These alterations must be due to changes in protein turnover. This review is, therefore, primarily concerned with investigating the mechanisms whereby tissue protein synthesis or degradation is altered as a consequence of ethanol toxicity. Attention will be focused on the various muscle types (i.e. skeletal, cardiac and smooth muscle) and bone.

Keywords

Muscle Protein Synthesis Specific Radioactivity Chronic Ethanol Label Amino Acid Skeletal Muscle Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

Si

specific radioactivity of free amino acid in intracellular space

Sp

specific radioactivity of free amino acid in extracellular space

SB

specific radioactivity of protein-bound amino acid

kS

fractional synthesis rate

kd

fractional degradation rate

kg

fractional growth rate

kRNA

RNA activity, ie amount of protein synthesis per unit RNA

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Victor R. Preedy
    • 1
  • Tahir Siddiq
    • 2
  • Elisabeth Cook
    • 1
  • Darcey Black
    • 3
  • T. Norman Palmer
    • 4
  • Timothy J. Peters
    • 1
  1. 1.Departments of Clinical BiochemistryKing’s College School of Medicine and DentistryLondonUK
  2. 2.Departments of CardiologyKing’s College School of Medicine and DentistryLondonUK
  3. 3.Department of Cellular SciencesGlaxo Group ResearchGreenford, MiddlesexUK
  4. 4.Department of BiochemistryUniversity of Western AustraliaPerthAustralia

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