Effects of Ethanol on the Rat Medial Septum Nucleus: An in Vivo Study
Among basal forebrain structures, the medial septum and diagonal band complex (MSDB) is interesting because it provides the major source of extrinsic cholinergic fibers to the hippocampus (Lewis and Shute, 1967; Mellgren and Srebo, 1973; Amaral and Kurz, 1985). Physiological and pharmacological studies have provided evidence that this septohippocampal projection plays a major role in the rhythmic slow activity (theta rhythm) of the hippocampal formation (Bland, 1986). Furthermore, cholinergic septal neurons seem to be necessary for the achievement of learning tasks by the hippocampus (Ikegami et al., 1989).
KeywordsHippocampal Formation Theta Rhythm Medial Septum Lateral Septum Acute Ethanol
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