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Alcoholism pp 197–209Cite as

Structural Changes in the Hippocampal Formation and Frontal Cortex after Long-Term Alcohol Consumption and Withdrawal in the Rat

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Part of the book series: NATO ASI Series ((NSSA,volume 206))

Abstract

Alcohol-induced neurocytological changes in humans were first reported by Courville (1955). However, such changes needed to be cautiously interpreted because other factors, as vitamin deficiency (Yew et al., 1981) and malnutrition (Victor and Adams,1961; Paula-Barbosa et al., 1989), commonly accompany chronic alcohol consumption (CAC) and are known also to affect the neuronal structure. Thus, the pioneer results obtained by Riley and Walker (1978) were of paramount importance because they described marked neuronal loss in the rodent hippocampal formation after 5 months of alcohol intake using a nutritional-controlled model.

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Authors and Affiliations

  1. Department of Anatomy Porto Medical School, Alameda Hernani Monteiro, 4200, Porto, Portugal

    A. Cadete-Leite

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  1. A. Cadete-Leite
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  1. The University of Western Australia, Nedlands, Perth, Australia

    T. Norman Palmer

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© 1991 Plenum Press, New York

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Cadete-Leite, A. (1991). Structural Changes in the Hippocampal Formation and Frontal Cortex after Long-Term Alcohol Consumption and Withdrawal in the Rat. In: Palmer, T.N. (eds) Alcoholism. NATO ASI Series, vol 206. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5946-3_21

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  • DOI: https://doi.org/10.1007/978-1-4684-5946-3_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5948-7

  • Online ISBN: 978-1-4684-5946-3

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