Structural Changes in the Hippocampal Formation and Frontal Cortex after Long-Term Alcohol Consumption and Withdrawal in the Rat
Alcohol-induced neurocytological changes in humans were first reported by Courville (1955). However, such changes needed to be cautiously interpreted because other factors, as vitamin deficiency (Yew et al., 1981) and malnutrition (Victor and Adams,1961; Paula-Barbosa et al., 1989), commonly accompany chronic alcohol consumption (CAC) and are known also to affect the neuronal structure. Thus, the pioneer results obtained by Riley and Walker (1978) were of paramount importance because they described marked neuronal loss in the rodent hippocampal formation after 5 months of alcohol intake using a nutritional-controlled model.
KeywordsGranule Cell Dendritic Spine Numerical Density Chronic Alcohol Consumption Withdrawal Group
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