Alcoholism pp 197-209 | Cite as

Structural Changes in the Hippocampal Formation and Frontal Cortex after Long-Term Alcohol Consumption and Withdrawal in the Rat

  • A. Cadete-Leite
Part of the NATO ASI Series book series (NSSA, volume 206)


Alcohol-induced neurocytological changes in humans were first reported by Courville (1955). However, such changes needed to be cautiously interpreted because other factors, as vitamin deficiency (Yew et al., 1981) and malnutrition (Victor and Adams,1961; Paula-Barbosa et al., 1989), commonly accompany chronic alcohol consumption (CAC) and are known also to affect the neuronal structure. Thus, the pioneer results obtained by Riley and Walker (1978) were of paramount importance because they described marked neuronal loss in the rodent hippocampal formation after 5 months of alcohol intake using a nutritional-controlled model.


Granule Cell Dendritic Spine Numerical Density Chronic Alcohol Consumption Withdrawal Group 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • A. Cadete-Leite
    • 1
  1. 1.Department of Anatomy Porto Medical SchoolAlameda Hernani MonteiroPortoPortugal

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