Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Their Significance for Alcohol-Related Problems
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) isozymes not only play a role in alcohol detoxification, but also participate in metabolism of neurotransmitters, fatty acids and glutathione, and in clearance of biogenic toxic substances. Genetic abnormalities, and consequent alteration of activity and kinetic properties of any one of the ADH and ALDH isozymes would potentially affect one’s sensitivity to alcohol and vulnerability in developing alcohol-related problems.
KeywordsAldehyde Dehydrogenase Alcoholic Liver Disease Ethanol Oxidation Restriction Fragment Length Polymorphism ALDH2 Gene
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- Harada, S., Muramatsu, T., and Agarwal, D. P., and Goedde, H. W., 1989, Polymorphism of aldehyde dehydrogenase in human saliva, Prog.Clin.Biol. Res., 190: 133.Google Scholar
- Hsu, L. C., Bendel, R. E., and Yoshida, A., 1987, Direct detection of usual and atypical alleles on human aldehyde dehydrogenase-2 (ALDH2) locus, Am.J. Hum.Genet., 41: 1987Google Scholar
- Hsu, L. C., Chang, W-C., and Yoshida, A., 1989, Cloning of a new human aldehyde dehydrogenase gene and comparison with liver cytosolic ALDH1 and mitochondria) ALDH2 genes, Am.J.Hum.Genet., 45: A196.Google Scholar
- O’Dowd, B. F., Rothhammer, F., and Israel, Y., 1990, Genotyping of mitochondrial aldehyde dehydrogenase locus of native South American Indians, Alcoholism Clin.Exp.Res., in press.Google Scholar
- Shibuya, A., and Yoshida, A., 1988b, Genotypes of alcohol metabolizing enzymes in Japanese with alcoholic liver disease: A strong association of the usual Caucasian type aldehyde dehydrogenase gene (ALDH21) with the disease, Am.J.Hum.Genet., 34: 744.Google Scholar
- Singh, S., Fritz, G., Fang, B., Harada, S., Paik, Y. K., Eckey, R., Agarwal, D. P., and Goedde, H. W., 1989, Inheritance of mitochondrial aldehyde dehydrogenase: Genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele, Hum.Genet., 83: 119.PubMedCrossRefGoogle Scholar
- Yin, S-J., Cheng, T-C., Chang, C-P., Chen, Y-J., Chao, Y-C., Tang, H-S., Chang, T-M., and Wu, C-W., 1988, Human stomach alcohol and aldehyde dehydrogenase (ALDH): A genetic model proposed for ALDH III isozymes, Bioch.Genet., 26: 345.Google Scholar
- Yoshida, A., 1983, A possible structural variant of human cytosolic aldehyde dehydrogenase with diminished activity, Am.J.Hum.Genet., 35: 1115.Google Scholar
- Yoshida, A., Hsu, L. C., and Yasunami, M., 1990, Genetics of human alcoholmetabolizing enzymes, in: “Progress in Nucleic Acid Research and Molecular Biology,” W. Cohn and K. Moldave, eds., Academic Press, Orlando, in press.Google Scholar
- Yoshida, A., Shibuya, A., Davé, V., Nakayama, M., and Hayashi, A., 1990, Developmental changes of aldehyde dehydrogenase isozymes in human livers: Mitochondrial ALDH2 isozyme is expressed in fetal livers, Experientia, in press.Google Scholar