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Alcoholism pp 127-138 | Cite as

Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Their Significance for Alcohol-Related Problems

  • A. Yoshida
Part of the NATO ASI Series book series (NSSA, volume 206)

Abstract

Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) isozymes not only play a role in alcohol detoxification, but also participate in metabolism of neurotransmitters, fatty acids and glutathione, and in clearance of biogenic toxic substances. Genetic abnormalities, and consequent alteration of activity and kinetic properties of any one of the ADH and ALDH isozymes would potentially affect one’s sensitivity to alcohol and vulnerability in developing alcohol-related problems.

Keywords

Aldehyde Dehydrogenase Alcoholic Liver Disease Ethanol Oxidation Restriction Fragment Length Polymorphism ALDH2 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • A. Yoshida
    • 1
  1. 1.Department of Biochemical GeneticsBeckman Research Institute of the City of HopeDuarteUSA

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