Diversity, Development, Ligands, and Probable Functions of γδ T Cells

  • Susumu Tonegawa
  • Anton Berns
  • Marc Bonneville
  • Andrew G. Farr
  • Isao Ishida
  • Kouich Ito
  • Shigeyoshi Itohara
  • Charles A. JanewayJr.
  • Osami Kanagawa
  • Ralph Kubo
  • Juan J. Lafaille
  • Donal B. Murphy
  • Nobuki Nakanishi
  • Yohtaro Takagaki
  • Sjek Veebeek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 292)


The most critical step in the vertebrate immune response is the recognition of antigens by lymphocytes. This task is accomplished by two sets of glycoproteins, immunoglobulins and T cell antigen-receptors (TCRs). The most extraordinary feature of these proteins is their structural variability, much of which originates from the ability of the encoding gene segments to undergo somatic rearrangement.1 All TCRs were initially thought to be composed of a heterodimeric protein composed of α and β subunits. However, the search for the genes encoding these polypeptides led to the identification of a third rearranging gene2,3 which was later shown to code for one of the two subunits of another heterodimeric, TCR γδ.4–6


Peripheral Lymphoid Organ Somatic Rearrangement Junctional Diversity Adult Thymus Intestinal Intraepithelial Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Susumu Tonegawa
    • 1
  • Anton Berns
    • 2
  • Marc Bonneville
    • 1
  • Andrew G. Farr
    • 3
  • Isao Ishida
    • 1
  • Kouich Ito
    • 1
  • Shigeyoshi Itohara
    • 1
  • Charles A. JanewayJr.
    • 4
  • Osami Kanagawa
    • 5
  • Ralph Kubo
    • 6
  • Juan J. Lafaille
    • 1
  • Donal B. Murphy
    • 7
  • Nobuki Nakanishi
    • 1
  • Yohtaro Takagaki
    • 1
  • Sjek Veebeek
    • 2
  1. 1.Howard Hughes Medical Institute Center for Research, Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.The Netherlands Cancer Institute, Division of Molecular Genetics and Department of ChemistryUniversity of AmsterdamThe Netherlands
  3. 3.Department of Biological StructureUniversity of WashingtonSeattleUSA
  4. 4.Howard Hughes Medical InstituteYale University Medical SchoolNew HavenUSA
  5. 5.Eli Lilly Research LaboratoriesLa JollaUSA
  6. 6.National Jewish Center of Immunology and Respiratory MedicineDenverUSA
  7. 7.The Wadsworth CenterNew York State Department of HealthAlbanyUSA

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