Life and Death of a T Cell
Thymus-derived lymphocytes or T cells recognize nominal antigens in the context of the products of the self major histocompatibility locus (MHC)--a phenomenon called MHC restriction. In addition, T cells must be self-tolerant to antigens that are endogenous to the organism in order to avoid an autoimmune condition. How the developing T cells acquire these two characteristics is the main theme of my laboratory.
KeywordsClonal Deletion Howard Hughes Medical Institute Thymocyte Development Double Positive Stage Major Histocompatibility Locus
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