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Life and Death of a T Cell

  • Dennis Y. Loh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 292)

Abstract

Thymus-derived lymphocytes or T cells recognize nominal antigens in the context of the products of the self major histocompatibility locus (MHC)--a phenomenon called MHC restriction. In addition, T cells must be self-tolerant to antigens that are endogenous to the organism in order to avoid an autoimmune condition. How the developing T cells acquire these two characteristics is the main theme of my laboratory.

Keywords

Clonal Deletion Howard Hughes Medical Institute Thymocyte Development Double Positive Stage Major Histocompatibility Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W. C. Sha, C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh, Selective expression of an antigen receptor on CD8-bearing T lymphocytes in trans-genic mice, Nature 335:271 (1988).PubMedCrossRefGoogle Scholar
  2. 2.
    W. C. Sha, C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh, Positive and negative selection of an antigen receptor on T cells in transgenic mice, Nature 336:73 (1988).PubMedCrossRefGoogle Scholar
  3. 3.
    W. C. Sha, C. A. Nelson, R. D. Newberry, J. K. Pullen, L. R. Pease, J. H. Russell, and D. Y. Loh, Positive selection of transgenic receptor-bearing thymocytes by Kb mutations that involve peptide binding, Proc. Natl. Aca. Sci. USA (in press, 1990).Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Dennis Y. Loh
    • 1
  1. 1.Howard Hughes Medical Institute, Department of Medicine, Genetics, Molecular MicrobiologyWashington University School of MedicineSt. LouisUSA

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