Identification of Components of the B Cell Antigen Receptor Complex
Immunoglobulins (Ig) are well-known as antibody molecules which are present in the serum of all vertebrate species. The mouse has five classes of Ig (IgM, IgD, IgG, IgA and IgE) and most of these antibody classes have different effector function during an immune response.1 Heavy chains of each Ig class exist also in a membrane-bound form23 which is expressed on the B cell surface as part of the antigen receptor. During B cell development the different antigen receptors are expressed in an ordered fashion.4 Immature B cells carry only surface Ig (slg) of the IgM class5 while mature B cells co-express slgM and slgD.6,7 Upon activation some B cells are generated which after a class switch express slgG, slgA or slgE. Cells with these antigen receptors are dominant in the pool of memory B cells.
KeywordsLymphoma Electrophoresis Myeloma Sorting Thymidine
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- 25.E. A. Kabat, T. T. Wu, M. Reid-Miller, H. M. Perry, and K. S. Gottesman, 1987, “Sequences of Proteins of Immunological Interest”, U. S. Department of Health and Human Services.Google Scholar