Induction and Maintenance of Anergy in Mature T Cells

  • Marc K. Jenkins
  • Daniel Mueller
  • Ronald H. Schwartz
  • Simon Carding
  • Kim Bottomley
  • Miguel J. Stadecker
  • Kevin B. Urdahl
  • Steven D. Norton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 292)


Three models have been proposed to explain the inability of T lymphocytes to respond to self-antigens (reviewed in 1): (a) self-reactive T cells are present but are prevented from functioning by suppressor T cells (suppression); (b) self-reactive T cells are present but have been functionally inactivated following interaction with host antigens (clonal anergy); and (c) self-reactive T cells are physically deleted (clonal deletion). A growing body of conclusive evidence indicates that clonal deletion is a major mechanism of tolerance induction for those antigens expressed in the thymus, the site of T cell development.2–5 It is difficult, however, to understand how this mechanism could account for tolerance to tissue-specific antigens, expressed in low amounts outside of the thymus. A potential resolution to this paradox may be found in recent studies that provide in vivo evidence for a nondeletional mechanism of clonal anergy6–8 that may operate outside of the thymus. The characteristics of the anergy observed in vivo are strikingly similar to those described for the induction of unresponsiveness in vitro for type 1 CD4+ T cell clones. Here we review our results on the induction of anergy in T cell clones and present new data on the mechanism by which it is maintained.


Cell Clone Antigenic Peptide Inositol Phosphate Thymic Epithelial Cell Clonal Deletion 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Marc K. Jenkins
    • 1
  • Daniel Mueller
    • 2
  • Ronald H. Schwartz
    • 2
  • Simon Carding
    • 3
  • Kim Bottomley
    • 3
  • Miguel J. Stadecker
    • 4
  • Kevin B. Urdahl
    • 1
  • Steven D. Norton
    • 1
  1. 1.Department of MicrobiologyUniversity of MinnesotaMinneapolisUSA
  2. 2.National Institute of Allergy and Infectious Disease, Laboratory of Cellular and Molecular ImmunologyNational Institutes of HealthBethesdaUSA
  3. 3.Howard Hughes Medical Institute, Section of ImmunobiologyYale University School of MedicineNew HavenUSA
  4. 4.Department of PathologyTufts University School of MedicineBostonUSA

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