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Multiple Mechanisms of T Cell Tolerance to Mls-la

  • Marcia A. Blackman
  • John W. Kappler
  • Philippa Marrack
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 292)

Abstract

A fundamental role of the immune system is to identify and destroy foreign antigens (Ag). A critical requirement of this function is the ability to distinguish between what is foreign, and should be eliminated, and what is “self” and should be tolerated. This lack of response to self is termed self-tolerance. Three mechanisms have been proposed for maintaining self tolerance-clonal deletion, or elimination of self-reactive clones, clonal anergy, or functional inactivation of self-reactive clones, and suppression, or negative regulation of self-reactive clones.

Keywords

Transgenic Mouse Major Histocompatibility Complex Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Cell Tolerance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Marcia A. Blackman
    • 1
    • 2
  • John W. Kappler
    • 1
    • 2
    • 4
  • Philippa Marrack
    • 1
    • 2
    • 3
    • 4
  1. 1.Howard Hughes Medical Institute at DenverNational Jewish Center for Immunology and Respiratory MedicineDenverUSA
  2. 2.Division of Basic Immunology, Department of MedicineNational Jewish Center for Immunology and Respiratory MedicineDenverUSA
  3. 3.Department of Biochemistry, Biophysics and GeneticsUniversity of Colorado Health Sciences CenterDenverUSA
  4. 4.Department of Microbiology, Immunology and MedicineUniversity of Colorado Health Sciences CenterDenverUSA

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