Multiple Mechanisms of T Cell Tolerance to Mls-la
A fundamental role of the immune system is to identify and destroy foreign antigens (Ag). A critical requirement of this function is the ability to distinguish between what is foreign, and should be eliminated, and what is “self” and should be tolerated. This lack of response to self is termed self-tolerance. Three mechanisms have been proposed for maintaining self tolerance-clonal deletion, or elimination of self-reactive clones, clonal anergy, or functional inactivation of self-reactive clones, and suppression, or negative regulation of self-reactive clones.
KeywordsTransgenic Mouse Major Histocompatibility Complex Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Cell Tolerance
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