Cells Inducing Tolerance to Mls and H-2 Antigens

  • Susan R. Webb
  • Jonathan Sprent
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 292)


The thymus shapes the T cell repertoire by selecting T cells which recognize foreign antigens in association with self major histocompatibility complex (MHC) molecules and by tolerizing those cells which have the potential to react to self antigens.1,2 There is now convincing evidence that negative selection (tolerance induction) of potentially self-reactive cells can occur by a process of clonal deletion.3-5 Direct support for this viewpoint has come from studies with monoclonal antibodies (mAB) specific for particular T cell receptor (TCR) Vβ gene products. Thus, it has been found that mature T cells bearing Vβ11, Vβ17, and Vβ5-positive TCRs are selectively deleted in I-E-positive mouse strains, presumably because these TCRs have high reactivity for I-E molecules (perhaps complexed with self peptides).6–8 Similar results are found for Mls antigens, a set of poorly characterized self antigens which have the unusual property of stimulating very high primary mixed lymphocyte responses (MLR).9,10 Thus, Mlsa-positive mouse strains delete Vβ6 and Vβ8.1-positive T cells and Mlsc-positive strains delete T cells bearing Vβ3.11–14


Major Histocompatibility Complex Tolerance Induction Cell Tolerance Clonal Deletion Major Histocompatibility Complex Antigen 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Susan R. Webb
    • 1
  • Jonathan Sprent
    • 1
  1. 1.Department of ImmunologyResearch Institute of Scripps ClinicLa JollaUSA

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