Monoclonal Antibodies Against T Cell Receptor/CD3 Complex Induce Cell Death of Th1 Clones in the Absence of Accessory Cells

  • Yang Liu
  • Charles A. JanewayJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 292)


The T cells respond to foreign antigens by clonal expansion but respond to self components by clonal deletion or functional inactivation.1–3 The specificity of these different responses is dictated by the T cell antigen receptor (TCR) which recognizes peptides associated with MHC antigens and transduces signals. Numerous studies indicate that such recognition can result in a variety of consequences, including cell proliferation, cytokine production, cell death,4 and clonal anergy.5 However, the mechanisms by which the outcomes of T cell recognition is determined are largely unknown.


Accessory Cell Clonal Deletion Inhibit Cell Death Lymphocyte Separation Medium Fetal Thymus 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Yang Liu
    • 1
  • Charles A. JanewayJr.
    • 1
  1. 1.Section of ImmunobiologyYale University School of Medicine, Howard Hughes Medical InstituteNew HavenUSA

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