Monoclonal Antibodies Against T Cell Receptor/CD3 Complex Induce Cell Death of Th1 Clones in the Absence of Accessory Cells
The T cells respond to foreign antigens by clonal expansion but respond to self components by clonal deletion or functional inactivation.1–3 The specificity of these different responses is dictated by the T cell antigen receptor (TCR) which recognizes peptides associated with MHC antigens and transduces signals. Numerous studies indicate that such recognition can result in a variety of consequences, including cell proliferation, cytokine production, cell death,4 and clonal anergy.5 However, the mechanisms by which the outcomes of T cell recognition is determined are largely unknown.
KeywordsAccessory Cell Clonal Deletion Inhibit Cell Death Lymphocyte Separation Medium Fetal Thymus
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