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Molecular and Genetic Analyses at the CF Locus

  • K. W. Klinger
  • P. Stanislovitis
  • J. Merrill
  • G. T. Horn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 290)

Abstract

Cystic fibrosis (CF) is the most frequent lethal autosomal recessive disorder of Caucasian populations. The disease incidence is commonly quoted as 1 in 2500 (Boat et al., 1989), but varies widely in different populations. Frequencies as low as 1:90,000 exist (Wright and Morton, 1968), and as high as 1:377 in Brittany (Bois et al., 1978), 1:313 in the Alberta Hutterites (Fujiwara et al., 1989), and 1:569 in the Ohio Old Order Amish (Klinger 1983). There has always been some question as to whether these diverse populations represented the same mutation.

Keywords

Cystic Fibrosis Cystic Fibrosis Gene Cystic Fibrosis Child Cystic Fibrosis Chromosome Cystic Fibro 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • K. W. Klinger
    • 1
  • P. Stanislovitis
    • 1
  • J. Merrill
    • 1
  • G. T. Horn
    • 1
  1. 1.Integrated GeneticsFraminghamUSA

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