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2D-Electrophoresis of Mitochondrial Proteins from Cystic Fibrosis Patients

  • L. Picci
  • L. Brentagni
  • G. Mastella
  • E. Scarso
  • P. Pizzochero
  • P. Mattiazzo
  • L. Chiandetti
  • F. Anglani
  • F. Zacchello
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 290)

Abstract

Experimental data from some laboratories (increased mitochondrial Ca++ concentration, increased O2 consumption, response to inhibitors, altered enzyme kinetics) point to a deranged mitochondrial function in cystic fibrosis (CF) (Burton and Shapiro, 1989).

Keywords

Cystic Fibrosis Mitochondrial Protein Cystic Fibrosis Patient Control sUbjects Italy Introduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Burton, L., Shapiro, B.L., 1989, Evidence for a mitochondrial lesion in cystic fibrosis, Life Sciences, 44:13 27.Google Scholar
  2. Smith, P.K., Krohn, R.I., Hermanson, G.T., Mallia, A.K.,Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J., Klenk, D.C., 1985, Measurement of protein using Bicinchoninic acid, Anal. Biochem., 150:76.PubMedCrossRefGoogle Scholar
  3. O’Farrell, P.H., 1975, High resolution two-dimensional electrophoresis of proteins, J. Biol. Chem., 250:4007.PubMedGoogle Scholar
  4. Merril, C.R., Goldman, D., 1981, Ultrasensitive stain for proteins in Polyacrylamide gels shows regional variation in cerebrospinal fluid proteins, Science, 211:1437.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • L. Picci
    • 1
  • L. Brentagni
    • 1
  • G. Mastella
    • 2
  • E. Scarso
    • 1
  • P. Pizzochero
    • 1
  • P. Mattiazzo
    • 1
  • L. Chiandetti
    • 1
  • F. Anglani
    • 1
  • F. Zacchello
    • 1
  1. 1.Dept. of PediatricsUniversity of PadovaItaly
  2. 2.Cystic Fibrosis CenterBorgo Trento HospitalVeronaItaly

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