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The Prevalence of the Deletion F508 in a Belgian Cystic Fibrosis Population

  • W. Lissens
  • M. Bonduelle
  • A. Malfroot
  • I. Dab
  • I. Liebaers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 290)

Abstract

We have used the polymerase chain reaction and dot blot analysis (Kerem et al., 1989) to screen for the deletion F508 in 75 Belgian families with at least one CF patient. Haplotype analysis with DNA probes XV-2c and KM19 had already been performed in most of these families (Devoto et al., 1989). The combined results are given in table 1. The frequency of the deletion F508 was 78.7% (118 of 150 CF chromosomes).

Keywords

Cystic Fibrosis Restriction Site Cystic Fibrosis Patient Pancreatic Insufficiency Normal Allele 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Devoto, M., L. De Benedetti., M. Seia, L. Piceni Sereni, M. Ferrari, M.L. Bonduelle, A. Malfroot, W. Lissens, A. Balas-sopoulou, G. Adam, D. Loukopoulos, P. Cochaux, G. Vassart, R. Szibor, J. Hein, K. Grade, W. Berger, B. Wainwright, and G. Romeo, 1989, Haplotypes in cystic fibrosis patients with or without pancreatic insufficiency from four European populations, Genomics, 5:894.PubMedCrossRefGoogle Scholar
  2. 2.
    Kerem, B-S., J.M. Rommens, J.A. Buchanan, D. Markiewicz, T.K. Cox, A. Chakravarti, M. Buchwald, L.-C. Tsui, 1989. Identification of the cystic fibrosis gene : genetic analysis. Science, 245:1073.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • W. Lissens
    • 1
  • M. Bonduelle
    • 1
  • A. Malfroot
    • 2
  • I. Dab
    • 2
  • I. Liebaers
    • 1
  1. 1.Departments of Medical GeneticsA.Z. -Vrije Universiteit BrusselBrusselsBelgium
  2. 2.Departments of PediatryA.Z. -Vrije Universiteit BrusselBrusselsBelgium

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