The Prevalence of the Deletion F508 in a Belgian Cystic Fibrosis Population
We have used the polymerase chain reaction and dot blot analysis (Kerem et al., 1989) to screen for the deletion F508 in 75 Belgian families with at least one CF patient. Haplotype analysis with DNA probes XV-2c and KM19 had already been performed in most of these families (Devoto et al., 1989). The combined results are given in table 1. The frequency of the deletion F508 was 78.7% (118 of 150 CF chromosomes).
KeywordsCystic Fibrosis Restriction Site Cystic Fibrosis Patient Pancreatic Insufficiency Normal Allele
- 1.Devoto, M., L. De Benedetti., M. Seia, L. Piceni Sereni, M. Ferrari, M.L. Bonduelle, A. Malfroot, W. Lissens, A. Balas-sopoulou, G. Adam, D. Loukopoulos, P. Cochaux, G. Vassart, R. Szibor, J. Hein, K. Grade, W. Berger, B. Wainwright, and G. Romeo, 1989, Haplotypes in cystic fibrosis patients with or without pancreatic insufficiency from four European populations, Genomics, 5:894.PubMedCrossRefGoogle Scholar