Abstract
We have used the polymerase chain reaction and dot blot analysis (Kerem et al., 1989) to screen for the deletion F508 in 75 Belgian families with at least one CF patient. Haplotype analysis with DNA probes XV-2c and KM19 had already been performed in most of these families (Devoto et al., 1989). The combined results are given in table 1. The frequency of the deletion F508 was 78.7% (118 of 150 CF chromosomes).
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References
Devoto, M., L. De Benedetti., M. Seia, L. Piceni Sereni, M. Ferrari, M.L. Bonduelle, A. Malfroot, W. Lissens, A. Balas-sopoulou, G. Adam, D. Loukopoulos, P. Cochaux, G. Vassart, R. Szibor, J. Hein, K. Grade, W. Berger, B. Wainwright, and G. Romeo, 1989, Haplotypes in cystic fibrosis patients with or without pancreatic insufficiency from four European populations, Genomics, 5:894.
Kerem, B-S., J.M. Rommens, J.A. Buchanan, D. Markiewicz, T.K. Cox, A. Chakravarti, M. Buchwald, L.-C. Tsui, 1989. Identification of the cystic fibrosis gene : genetic analysis. Science, 245:1073.
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© 1991 Springer Science+Business Media New York
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Lissens, W., Bonduelle, M., Malfroot, A., Dab, I., Liebaers, I. (1991). The Prevalence of the Deletion F508 in a Belgian Cystic Fibrosis Population. In: Tsui, LC., Romeo, G., Greger, R., Gorini, S. (eds) The Identification of the CF (Cystic Fibrosis) Gene. Advances in Experimental Medicine and Biology, vol 290. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5934-0_40
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DOI: https://doi.org/10.1007/978-1-4684-5934-0_40
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