Cystic Fibrosis in the Sicilian Population: Linkage Disequilibrium and Prenatal Diagnosis by Polimerase Chain Reaction
We have been studying 106 chromosomes from 21 Sicilian families with one or more subjects affected with cystic fibrosis. Using XV2C and KM19 probes we have shown a linkage disequilibrium between haplotype B and CF allele (68%). However this association was less frequent than previously described in other Caucasian CF families (Estivill et al., 1987; Vidaud et al., 1989; Weber et al., 1988). Moreover, the presence in our population of a higher frequency of haplotype A (15.7%) compared to European and North American population was found, suggesting some heterogeneity of CF gene defects in our country.
KeywordsLinkage Disequilibrium Cystic Fibrosis Prenatal Diagnosis North American Population Cystic Fibrosis Gene
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