Abstract
We have been studying 106 chromosomes from 21 Sicilian families with one or more subjects affected with cystic fibrosis. Using XV2C and KM19 probes we have shown a linkage disequilibrium between haplotype B and CF allele (68%). However this association was less frequent than previously described in other Caucasian CF families (Estivill et al., 1987; Vidaud et al., 1989; Weber et al., 1988). Moreover, the presence in our population of a higher frequency of haplotype A (15.7%) compared to European and North American population was found, suggesting some heterogeneity of CF gene defects in our country.
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© 1991 Springer Science+Business Media New York
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D’Alcamo, E. et al. (1991). Cystic Fibrosis in the Sicilian Population: Linkage Disequilibrium and Prenatal Diagnosis by Polimerase Chain Reaction. In: Tsui, LC., Romeo, G., Greger, R., Gorini, S. (eds) The Identification of the CF (Cystic Fibrosis) Gene. Advances in Experimental Medicine and Biology, vol 290. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5934-0_35
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DOI: https://doi.org/10.1007/978-1-4684-5934-0_35
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