DNA Analysis in CF Families by Biotinylated Probes and Polymerase Chain Reaction Technique
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 290)
About 70% of the mutations in the cystic fibrosis (CF) gene in North American, British and Dutch patients are caused by a 3 bp deletion referred to as DeltaF508 (Kerem et al., 1989).
KeywordsCystic Fibrosis Prenatal Diagnosis Polymerase Chain Reaction Technique Informative Pattern Carrier Detection
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- Anglani, F., Camporese, C., Greggio, N.A., Murgia, A., Zacchel-lo, F., 1990, The use of biotinylated probes in the DNA analysis for diagnostic purpose, CHIMICAoggi, Inter. J. of Chem. and Biotech., (in press).Google Scholar
- Mathew, C.G. ,Roberts, R.G., Harris, A., Bentley, D.P., Bobrow, M., 1989, Rapid screening for DeltaF508 deletion in Cystic Fibrosis, Lancet, II:1346.Google Scholar
© Springer Science+Business Media New York 1991