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Molecular Genetics of Cystic Fibrosis

  • L.-C. Tsui
  • J. Rommens
  • B. Kerem
  • R. Rozmahel
  • J. Zielenski
  • D. Kennedy
  • D. Markiewicz
  • N. Plavsic
  • J.-L. Chou
  • D. Bozon
  • M. Dobbs
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 290)

Abstract

The gene for cystic fibrosis (CF) has recently been isolated (Rommens et al., 1989a; Riordan et al., 1989; Kerem et al., 1989) rendering it possible for the first time to study the elusive symptoms of the disease. In this brief review, we try to summarize our current understanding of the CF gene and our attempts to study the gene product and its function. We have also included a short discussion on the correlation between genotype and phenotype in CF patients.

Keywords

Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Mouse Cystic Fibrosis Cystic Fibrosis Gene Cystic Fibrosis Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • L.-C. Tsui
    • 1
    • 2
  • J. Rommens
    • 1
    • 2
  • B. Kerem
    • 1
    • 2
  • R. Rozmahel
    • 1
    • 2
  • J. Zielenski
    • 1
    • 2
  • D. Kennedy
    • 1
    • 2
  • D. Markiewicz
    • 1
    • 2
  • N. Plavsic
    • 1
    • 2
  • J.-L. Chou
    • 1
    • 2
  • D. Bozon
    • 1
    • 2
  • M. Dobbs
    • 1
    • 2
  1. 1.Department of GeneticsThe Hospital for Sick ChildrenCanada
  2. 2.Departments of Medical Genetic and Medical BiophysicsUniversity of TorontoCanada

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