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Aerosolized Amiloride as Treatment of Cystic Fibrosis Lung Disease: A Pilot Study

  • Michael R. Knowles
  • Nina L. Church
  • William E. Waltner
  • James R. Yankaskas
  • Peter Gilligan
  • Malcolm King
  • Lloyd J. Edwards
  • Ronald W. Helms
  • Richard C. Boucher
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 290)

Abstract

Excessive Na+ absorption1,2 and defective regulation of apical membrane Cl- secretion3–6 likely leads to dehydration and abnormal rheology of CF airway secretions7. These abnormalities contribute to poor clearance of airway secretions, and chronic bacterial infection in CF. Because amiloride inhibits the absorption of Na+ (and liquid) across airway mucosa1,8,9 when applied to the apical surface of CF airway epithelia, we hypo-thesized that inhalation of amiloride may improve rheology and clearance of airway secretions9,10 This hypothesis was tested in a doubleblind crossover study to explore the safety and efficacy of long-term amiloride aerosol in the treatment of cystic fibrosis lung disease11.

Keywords

Cystic Fibrosis Force Vital Capacity Cystic Fibrosis Patient Total Lung Capacity Parenteral Antibiotic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Michael R. Knowles
    • 1
    • 2
  • Nina L. Church
    • 1
    • 2
  • William E. Waltner
    • 1
    • 2
  • James R. Yankaskas
    • 1
    • 2
  • Peter Gilligan
    • 1
    • 2
  • Malcolm King
    • 1
    • 2
  • Lloyd J. Edwards
    • 1
    • 2
  • Ronald W. Helms
    • 1
    • 2
  • Richard C. Boucher
    • 1
    • 2
  1. 1.The University of North CarolinaUSA
  2. 2.The University of AlbertaCanada

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