Advertisement

Present State of DNA-Diagnosis for Cystic Fibrosis and Attitudes Concerning a Heterozygote Screening in the GDR

  • Ch. Coutelle
  • K. Grade
  • A. Speer
  • K. Will
  • Chr. Gille
  • R. Szibor
  • J. Gedschold
  • R. Brückner
  • V. Steinbicker
  • I. Bauer
  • K. Giermann
  • H. Gorki
  • S. Meyer
  • J. Brock
  • J. Hein
  • U. Brell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 290)

Abstract

Beginning with 1986 a nationwide system of genomic-diagnosis for PKU, Cystic fibrosis and Duchenne/Becker Muscular Dystrophy involving six DNA-laboratories has been introduced to the health care system of the German Democratic Republic. It is based on the long-standing system of genetic registers and the social and medical care available free of charge for the affected individuals and their families in this country [1]•

Keywords

Cystic Fibrosis German Democratic Republic Prenatal Clinic Meconium Ileus Affected Pregnancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Coutelle, Ch., Speer,A., 1990, Genomics in the GDR, Genomics, in pressGoogle Scholar
  2. 2.
    Szibor, R., Weise, W., Gola, H., Roso, I., Gedschold, J., Steinbicker, V., Kropf, S., 1987, Pranatale Diagnostik der CF-Eine prospektive Studie auf der Basis der Bestimmung von Fruchtwasserenzymen und der Sonographie, Z. schr. Klin. Med., 42:783.Google Scholar
  3. 3.
    Berger, W., Hein J., Gedschold, J., Bauer, I., Speer, A., Farrall, M., Williamson, R., Coutelle, Ch., 1987,Crossovers in two German cystic fibrosis families determine probe order for MET, 7C22,and XV2c/C5.7, Human Genet., 77:187.Google Scholar
  4. 4.
    Estivill, X., Farrall, M, Scambler, P.J., Bell, G.M., Hawley, K.M.F., Lench, N.J., Bates, G.P., Kryer, H.C., Frederick, P.A., Stanier, P., Watson, E.K., Williamson, R., Wainwright, B.J., 1987, A candidate gene for the cystic fibrosis locus isolated by selection for methylation-free islands, Nature, 326:840.PubMedCrossRefGoogle Scholar
  5. 5.
    Grade, K., Will, K., Szibor, R., Gedschold, J., Bruckner, J., Bauer, I., Giermann, K., Gorki, H., Hein, J., Brell, U., Coutelle, Ch., 1990, First analysis of the Phe508-Deletion in cystic fibrosis patients from the GDR, Human Genet., in press.Google Scholar
  6. Gille, C., Grade, K., Coutelle, Ch., A multiplex approach to heterozygote screening for the F508 cystic fibrosis mutation, Human Genet., submitted.Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Ch. Coutelle
    • 1
  • K. Grade
    • 1
  • A. Speer
    • 1
  • K. Will
    • 1
  • Chr. Gille
    • 1
  • R. Szibor
    • 2
  • J. Gedschold
    • 2
  • R. Brückner
    • 2
  • V. Steinbicker
    • 2
  • I. Bauer
    • 3
  • K. Giermann
    • 3
  • H. Gorki
    • 3
  • S. Meyer
    • 3
  • J. Brock
    • 3
  • J. Hein
    • 4
  • U. Brell
    • 5
  1. 1.Centr. Inst. Molec. Biol.Acad. Sci. GDRBerlinGermany
  2. 2.Dept. Hum. Genet.Med. Acad.MagdeburgGermany
  3. 3.Inst. Biochem.WPURostockGermany
  4. 4.Pediatr. Clin.WPURostockGermany
  5. 5.111. Pediatr. Clin.Berlin-BuchGermany

Personalised recommendations