Relationships Between the Hypothalamus and Adipose Tissue Mass

  • Daniel A. K. Roncari
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 291)


A system influencing the availability of energy to the entire organism, expectedly, depends on a widespread network directed by the central nervous system. Indeed, there are complex interactions between “controllers” in the brain and peripheral mechanisms for energy consumption and release, as well as the complex machinery mediating chemical energy storage (predominantly as triglyceride) and mobilization. Critical afferent and efferent systems connect the hypothalamic and other brain centres which control food intake and energy disposal, with the relevant target sites. This brief review will summarize four mechanisms whereby the brain, particularly the hypothalamus along with its interconnecting neural structures, can influence body fat content.


Paraventricular Nucleus Increase Food Intake Decrease Food Intake Ventromedial Nucleus Acidic Fibroblast Growth Factor 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Daniel A. K. Roncari
    • 1
  1. 1.Institute of Medical Science and Departments of MedicineUniversity of Toronto and Sunnybrook Health Science CentreTorontoCanada

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