Novel Peptides and Islet Function

  • Kazuhiko Tatemoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 291)


Hormones and neurotransmitters are known to be involved in the regulation of islet function, and in recent years, it has become clear that neuropeptides released from pancreatic neurons may also be involved in the islet hormone release (1). Several hormones and neurotransmitters are known to inhibits insulin secretion. For example, noradrenaline (2) and somatostatin (3) inhibit insulin secretion from the pancreas. Between 1980 and 1986, we isolated a number of novel peptides and found that some strongly inhibit insulin secretion. This paper briefly summarizes studies on these inhibitory peptides, and describes their relations to islet function, and the potential use of their antagonists as drugs for diabetes.


Insulin Secretion Vasoactive Intestinal Peptide Pancreatic Polypeptide Glucagon Secretion Islet Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Kazuhiko Tatemoto
    • 1
  1. 1.Peptide Research Laboratory, Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA

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