Blood-Brain Barrier Transport of Glucose, Free Fatty Acids, and Ketone Bodies

  • William M. Pardridge
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 291)


Fuel homeostasis is important to the regulation of central nervous system (CNS) function because cerebral pathways of metabolism of glucose, ketone bodies, and amino acids are dependent upon plasma substrate availability. Therefore, brain function and brain metabolism are under nutritional regulation and the interface between diet or fuel homeostasis and brain function is the limiting transport barrier between blood and brain, which is the brain capillary endothelial wall, i.e., the blood-brain barrier (BBB) (Figure 1).


Free Fatty Acid Glucose Transporter Ketone Body Cerebral Blood Volume Experimental Diabetes 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • William M. Pardridge
    • 1
  1. 1.Department of Medicine and Brain Research InstituteUCLA School of MedicineLos AngelesUSA

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