Measurement of Local Cerebral Glucose Utilization and its Relation to Local Functional Activity in the Brain

  • Louis Sokoloff
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 291)


The average normal, human male brain represents approximately 2% of total body weight but consumes about 20% of the total body basal oxygen consumption (Sokoloff, 1989). The substrate for this high rate of energy metabolism is normally almost exclusively glucose (TABLE 1) (Sokoloff, 1960). In fact, more glucose is consumed than can be oxidized completely to carbon dioxide and water by the oxygen consumption, indicating that the glycolytic rate exceeds the rate of oxidation of the products of glycolysis, normally by about 20% (Table 1). The excess carbon derived from glycolytic utilization of glucose is probably distributed in many, e.g., lactate, pyruvate, and other intermediates of the glycolytic and tricarboxylic acid cycle pathways that leave the brain in amounts too insignificant to be detected in the cerebral blood, and also into several neurotransmitter pools, such as acetylcholine, glutamate, GABA, etc.


Operational Equation Glucose Utilization Hexose Transport Arterial Plasma Cerebral Glucose Utilization 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Louis Sokoloff
    • 1
  1. 1.National Institute of Mental HealthBethesdaUSA

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