Use of Peptide Probes to Study Brain Regulation of Glucose Metabolism
Peptides represent the largest class of biologically active ligand that exist within central nervous system (CNS) neurons and their axonal projections. The physiologic role that these peptides play in the regulation of brain cellular functions, including neurotransmission, has not been determined. Most brain peptides display biological actions when administered into the CNS, thus leading to hypotheses regarding their physiologic roles. In addition to characterization of the physiologic roles of these peptides within the CNS, it is evident that these substances may be utilized as neurochemical probes with unique specificities for select neuronal populations to study both cellular and integrated CNS functions. An area of importance to physiologists has been the use of peptides to modify brain neuroendocrine and autonomic nervous system neuro-humoral effector mechanisms that regulate visceral organ function. This chapter will describe some of the CNS peptides that may be used as probes to study neuroendocrine and autonomic control of glucose metabolism.
KeywordsGlucose Metabolism Blood Glucose Concentration Adrenal Medulla Central Command Central Nervous System Action
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