Optic Neuropathy in the Diabetic BB-Rat

  • Subrata Chakrabarti
  • Wei-Xian Zhang
  • Anders A. F. Sima
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 291)


Investigations of diabetic neuropathy have primarily been concerned with the distal symmetric mainly sensory and autonomic polyneuropathies. However in both clinical and experimental diabetes there are evidence to suggest both structural and functional involvements of the central nervous system1,2. In a recent report it was demonstrated that spinal cord conduction velocity declines in parallel with peripheral nerve conduction slowing suggesting a common mechanism responsible for both central and peripheral neuropathies in diabetes3.


Optic Nerve Diabetic Retinopathy Ganglion Cell Diabetic Neuropathy Optic Neuropathy 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Subrata Chakrabarti
    • 1
  • Wei-Xian Zhang
    • 1
  • Anders A. F. Sima
    • 1
  1. 1.Neuropathology Research Laboratories, Dept. of PathologyUniversity of ManitobaWinnipegCanada

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