Ribonuclease H and Primer tRNA Binding Activities of HIV Reverse Transcriptase as Therapeutic Targets

  • Stuart F. J. Le Grice
  • Oktavian Schatz
  • Jean-Luc Darlix
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Human immunodeficiency virus reverse transcriptase (RT, deoxynucleoside-triphosphate: DNA deoxynucleotidyltransferase (RNA-directed), E.C. has been the subject of intense investigation over the last 5 years, with the goal of developing a safe and effective therapy to stem the progression of AIDS. Although success has been achieved with inhibitors of viral replication such as AZT1–3, the rapid emergence of tolerance to this drug4 is a clear indication that new and improved therapies will be in constant demand for a considerable period.


Rous Sarcoma Virus Human Immunodeficiency Virus Reverse Transcriptase Replication Primer Proviral Clone Lymphoblastic Leukaemia Cell Line 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Stuart F. J. Le Grice
    • 1
  • Oktavian Schatz
    • 2
  • Jean-Luc Darlix
    • 3
  1. 1.Div. of Infectious DiseasesCWRU School of MedicineClevelandUSA
  2. 2.ZFE/BioHoffmann-La Roche Ltd.BaselSwitzerland
  3. 3.Labo-retroCRBCG du CNRSToulouseFrance

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