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Rous Sarcoma Virus Gag Gene Sequences Affect Viral RNA Splicing and Stability

  • Mark T. McNally
  • George F. Barker
  • Karen Beemon
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

A feature common to the life cycles of all retroviruses is the incomplete splicing of the primary viral RNA transcript. While splicing of a subset of the primary transcripts is necessary to generate subgenomic mRNAs (including env mRNA and additional mRNAs in the more complex retroviruses), a major fraction of the RNA transcripts are transported to the cytoplasm in an unspliced form, where they serve both as mRNA and as genomic RNA (Coffin, 1990; Stoltzfus, 1989).

Keywords

Splice Acceptor Site Triosephosphate Isomerase Rous Sarcoma Virus Nonsense Codon Field Virology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Mark T. McNally
    • 1
  • George F. Barker
    • 1
  • Karen Beemon
    • 1
  1. 1.Department of BiologyJohns Hopkins UniversityBaltimoreUSA

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