Red Blood Cells Exposing CD4, as Competitive Inhibitors of HIV-1 Infection

  • Claude Nicolau
  • David J. Volsky
  • Pierre-François Tosi
  • Youssef Mouneimne
  • Michael Zeira
  • Jaime Lazarte
  • Loyd Sneed
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Infection by human immunodeficiency virus (HIV) 1–3 is mediated by binding to CD4, a glycoprotein expressed on the surface of HIV-susceptible cells.4 The interaction between CD4 and the HIV envelope glycoprotein, gp120, was demonstrated by McDougal et al.,5 who coimmunoprecipitated the two proteins from infected cells. The affinity constant of the gp120-CD4 complex is about 4 x 10−9 M which is comparable to other virus-receptor interactions.6 Maddon et al.7 provided further evidence for the essential role of CD4 in HIV infection by introducing a functional CD4 gene into CD4 human cells, thereby conferring HIV susceptibility to previously resistant cells.


Human Immunodeficiency Virus Human Immunodeficiency Virus Type Human Immunodeficiency Virus Infection Anti FITC Antibody Human Immunodeficiency Virus Envelope Glycoprotein 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Claude Nicolau
    • 1
  • David J. Volsky
    • 2
  • Pierre-François Tosi
    • 1
  • Youssef Mouneimne
    • 1
  • Michael Zeira
    • 1
  • Jaime Lazarte
    • 1
  • Loyd Sneed
    • 1
  1. 1.Section of Cell Biology, Institute of Biosciences and TechnologyTexas A&M UniversityCollege StationUSA
  2. 2.Molecular Virology Laboratory, St. Luke’s Roosevelt Hospital Center and College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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