A T Cell Clone Which Reflects the Functional Defects Observed in the T Cells of AIDS Patients

  • V. L. Perez
  • T. M. Folks
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Infection of T cells by the Human Immunodeficiency Virus (HIV) renders the body susceptible to attack by opportunistic infections as these cells of the immune system are not only killed by the virus, but are also rendered defective in their function (1,2,3,4). It is well documented that T cell defects associated with HIV infection in AIDS patients include reduced production of the lymphokine, IL-2, and an inability to mobilize Ca++ following mitogenic or antigenic stimulation. T cell dysfunction has also been attributed to downmodulation of CD3 and CD4, possibly as a result in their uncoupling (5,6,7). Since many of these events that lead to T cell activation are under some of the same controls as events involved in the activation of HIV (8–9), a T cell model system to study physiologic influences on HIV expression and the effects of the virus on the cell’s activation signals would be of great value.


Human Immunodeficiency Virus Jurkat Cell Acquire Immunodeficiency Syndrome Inositol Triphosphate Cell Model System 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • V. L. Perez
    • 1
  • T. M. Folks
    • 1
  1. 1.Retrovirus Diseases Branch, Division of Viral and Rickettsial Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health ServiceU.S. Department of Health and Human ServicesAtlantaUSA

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