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CD4-Pseudomonas Exotoxin: A Strategy for AIDS Therapy Based on Selective Killing of HIV-Infected Cells

  • Per Ashorn
  • Bernard Moss
  • Edward A. Berger
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The receptor for human immunodeficiency virus (HIV) is CD4, a 55 kD glycoprotein expressed on the surface of certain human lymphoid and monocytic cell types1. The finding2–7 that recombinant soluble forms of CD4 retain the capacity for high affinity binding to gp120 (the external subunit of the HIV envelope glycoprotein) has suggested potential therapeutic uses of CD4 derivatives. For example, soluble truncated forms of CD4 (sCD4) are able to neutralize HIV infectivity in vitro 2–6,suggesting they may have specific anti-viral activity in HIV-infected individuals. Several “second-generation” applications of this neutralizing concept are under development, including attachment of the CD4 to immunoglobulin constant region sequences8–12, or presentation of the CD4 in association with erythrocytes13. These modifications provide the advantages of increased plasma half-life compared to sCD4, and possibly enhanced efficiency of neutralization due to multivalency.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Infected Cell Line Selective Killing Human Immunodeficiency Virus Spread 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Per Ashorn
    • 1
  • Bernard Moss
    • 1
  • Edward A. Berger
    • 1
  1. 1.Laboratory of Viral Diseases, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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