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Envelope Pseudotypes of HIV and HTLV

  • Nathaniel R. Landau
  • Kathleen A. Page
  • Dan R. Littman
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The course of viral infections can be influenced by a variety of host factors as well as by co-infection of the host with one or more other viruses. Studies in cells co-infected with the human immunodeficiency virus (HIV) and a second virus have demonstrated transactivation of transcription from the HIV LTR by products of the second virus. Several classes of viruses, including papovaviruses (6), herpesvirus (8, 13, 15) and hepatitis B virus (23) have been shown to have this transactivating property. A second virus can also activate transcription of HIV proviruses by indirect mechanisms, such as by inducing the transcription factor NFkB, which acts on the HIV LTR (14). The human T cell leukemia viruses (HTLV-I and HTLV-II) may enhance HIV replication by a different means; HTLV particles have a direct mitogenic effect on T cells (possibly by binding to a cell surface growth factor receptor) and thus stimulating production of HIV from infected T cells (5, 28).

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Type Envelope Glycoprotein Feline Immunodeficiency Virus Human Immunodeficiency Virus Infected Individual 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Nathaniel R. Landau
    • 1
  • Kathleen A. Page
    • 1
  • Dan R. Littman
    • 1
    • 2
  1. 1.Department of Microbiology and ImmunologyUniversity of California, San FranciscoSan FranciscoUSA
  2. 2.Howard Hughes Medical InstituteUniversity of California, San FranciscoSan FranciscoUSA

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