Molecular Functional Studies of HIV-1 REV and NEF Proteins

  • Sundararajan Venkatesan
  • Steven M. Holland
  • Nafees Ahmad
  • Paul Wingfield
  • Ratan K. Maitra
  • H. Clifford Lane
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Human immunodeficiency virus type 1 (HIV-1), the etiological agent of AIDS, preferentially infects the CD4+ helper subset of human T lymphocytes. Clinically, HIV-1 infection is characterized by a chronic phase lasting several years with a paucity of infected lymphocytes in the circulation. Notwithstanding, HIV-1 infection of primary human T lymphocytes or CD4+ cell lines in vitro leads to massive acute infection and cell death (20). This dichotomy between the natural history of virus infection and its behavior in tissue culture implies the existence of viral and cellular determinants of viral latency and reactivation.


Human Immunodeficiency Virus Jurkat Cell Provirus Expression Primate Immunodeficiency Virus 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Sundararajan Venkatesan
    • 1
  • Steven M. Holland
    • 1
  • Nafees Ahmad
    • 1
  • Paul Wingfield
  • Ratan K. Maitra
    • 1
  • H. Clifford Lane
    • 3
    • 2
  1. 1.Laboratory of Molecular MicrobiologyNational Institute of Allergy and Infectious DiseasesBethesdaUSA
  2. 2.Laboratory of ImmunoregulationNational Institute of Allergy and Infectious DiseasesBethesdaUSA
  3. 3.Protein Expression LaboratoryNational Institutes of HealthBethesdaUSA

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