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A 5’ Splice Site is Essential for REV and REX Regulation of HIV Envelope Protein mRNA Expression

  • Xiaobin Lu
  • Nancy Lewis
  • David Rekosh
  • Marie-Louise Hammarskjöld
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The organization of the HIV genome is much more complex than that of most other retroviruses (for a review see (1)). This is due to the presence of several regulatory genes in addition to the structural genes gag, pol and env. This complexity is reflected by the large number of different subgenomic mRNAs found in HIV infected cells (2). A proper balance between these mRNAs has to be achieved to ensure appropriate expression of the different viral proteins.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Type Splice Site Subgenomic mRNAs Human Immunodeficiency Virus Envelope Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Xiaobin Lu
    • 1
  • Nancy Lewis
    • 1
  • David Rekosh
    • 1
  • Marie-Louise Hammarskjöld
    • 1
  1. 1.Departments of Microbiology, Biochemistry, Biological Sciences and Oral BiologyState University of New York at BuffaloBuffaloUSA

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