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Trans-Activation Requires the Binding of the HIV-1 Tat Protein to Tar RNA

  • Colin Dingwall
  • Ingemar Ernberg
  • Michael J. Gait
  • Shaun Heaphy
  • Jonathan Karn
  • Michael Skinner
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The viral trans-activator protein, tat, stimulates HIV trans-cription by recognizing the transactivation-responsive region (TAR). Genetic experiments have shown that TAR is a cis-acting element which is located immediately downstream of the transcription start site, between nucleotides +1 and +59 (Dayton et al., 1986; Rosen et al., 1986; Fisher et al., 1986; Hauber et al., 1987; Muesing et al., 1987).

Keywords

Loop Sequence Cyanogen Bromide Nascent Transcript Bulge Region Filter Binding Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Colin Dingwall
    • 1
  • Ingemar Ernberg
    • 1
  • Michael J. Gait
    • 1
  • Shaun Heaphy
    • 1
  • Jonathan Karn
    • 1
  • Michael Skinner
    • 1
  1. 1.Medical Research Council Laboratory of Molecular BiologyCambridgeEngland

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